Health Effects of Ingested Fluoride (1993) / Chapter Skim
Currently Skimming:
5 EFFECTS OF INGESTED FLUORIDE ON RENAL, GASTROINTESTINAL, AND IMMUNE SYSTEMS
5 EFFECTS OF INGESTED FLUORIDE ON RENAL, GASTROINTESTINAL, AND IMMUNE SYSTEMS
Pages 85-90
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 85... ...
renal effects, such as polyuria, increased urinary pH, and proximal tubular cell necrosis. The renal effects in rodents are probably agedependent because suckling rats have a lower urinary pH than weanling rats do.
|
From page 86... ...
In humans, the potential for health effects of fluoride exposures on renal function is enhanced because of selective absorption by the kidney and the kinetics of fluoride distribution ant} excretion. The healthy kidney removes fluoride from the blooct much more efficiently than it removes the other halogens.
|
From page 87... ...
Hydrogen fluoride has been shown to induce structural and functional adverse effects on the gastric mucosa of rats and dogs at concentrations of 190 mg/L. These effects range from loss of the mucous layer and scattered desquamation of mucous cells to widespread erosions of the gastric mucosa (Whitford, 1990~.
|
From page 88... ...
There are limited data on humans at low exposures, indicating that at optimal concentrations of fluoride, gastrointestinal effects are not a problem. HYPERSENSITnnTY AND IMMUNOLOGICAL EFFECTS Few animal and human data on sodium fluoride-related hypersensitivity reactions are found in the literature.
|
From page 89... ...
Experimental studies of the effects of fluoride on the gastrointestinal tract in several animal species have shown dose-dependent adverse effects, such as chronic gastritis and lesions of the stomach mucosa, at doses as low as 190 mg/L. The limited reports on adverse gastrointestinal effects
|
From page 90... ...
Because of the lack of documented adverse effects on the renal and gastrointestinal systems et fluoride concentrations below S mg/L of drinking water, no research recommendations are made at this time. The literature pertaining to immunological and immunomodulation effects of fluoride is limited.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.