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The Chemistry of Microbiomes Proceedings of a Seminar Series (2017) / Chapter Skim
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8 Digitizing the Chemistry Associated with Microbes: Importance, Current Status, and Opportunities - Pieter C. Dorrestein
Pages 53-56

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From page 53...
... . There are three sources of chemicals associated with any ecological niche: the external niche chemistry imposed by the host, food, exposome, medications, and personal care derived molecules; microbially modified molecules; and microbiome genome encoded molecules.
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From page 54...
... While other methods exist for the characterization of chemicals, such as nuclear magnetic resonance, and infrared spectroscopies, engineered strains, or enzymatic systems to detect specific molecules, the focus of this presentation was mass spectrometry and challenges and the opportunities within this field to characterize the chemistry of the microbiome. Right now, we do not know the 10 most common microbial molecules that are found in the gut or what the 10 most influential molecules are that shape microbial community composition.
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From page 55...
... To date, and despite a decade of discussion on the importance of reusing it, there is only one study that has reused the raw metabolomics data of a previous study. However, mass spectrometry repositories have emerged in the last few years -- such as MetaboLights, XCMS Online, Metabolomics Workbench, and GNPS -- and are the first step to capture the data associated with microbiome chemical information (Gowda et al., 2014; da Silva et al., 2015; Kale et al., 2016)
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From page 56...
... 2016. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.
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Key Terms

  • mass spectrometry
  • gene clusters
  • metabolomics data
  • microbial communities
  • microbial molecules

  • natural products
  • similar gene
  • data inaccessible
  • natural product
  • shape microbial

  • microbiome project
  • gene sequences
  • reference data
  • bile acids
  • heterologous expression

  • structure elucidation
  • nat chem
  • chem biol
  • microrobotic monitoring
  • link dynamic

  • previous study
  • metabolic exchange
  • nuclear magnetic
  • consider microbes
  • genome encoded

  • roles associated
  • molecules isolated
  • play significant
  • bacterial communities
  • commonly accepted


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