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The Chemistry of Microbiomes Proceedings of a Seminar Series (2017) / Chapter Skim
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13 Epilogue After the Panel Discussions
Pages 93-96

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 93...
... Many genomic tools currently exist that can reveal the organisms present within a microbiome, but there is a challenge in integrating different types of data to reveal underlying mechanisms. The lack of a comprehensive understanding of individual organisms genetic complement in communities limits understanding of how individuals collectively work together as functional microbiomes to chemically interact with each other and their environment.
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From page 94...
... Such approaches could provide an outstanding framework for moving forward in microbiome chemistry research and asking important questions, such as how microbiomes may play critical roles in host function; microbiomes may be unseen instigators of interactions between higher organisms. Efforts may include understanding commonalities between microbiomes of different hosts, regions, and identifying whether patterns and similar interactions are occurring that can begin to formulate underlying principles of microbiome function.
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From page 95...
... Computational models, such as community flux balance, are critical for understanding, predicting, and engineering complex microbiomes, but such efforts are nascent. New approaches that rapidly develop discoveries and new knowledge into models can bridge current knowledge gaps using computation biology.
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From page 96...
... By simultaneously measuring fine-scale, dynamic chemical gradients -- in which microbial communities reside and interact -- with single cell measurements, we may be able to analyze the interactions between organisms at the scale that the interactions occur. The scale at which we currently probe the interactions between organisms is not at the scale interactions occur.
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Key Terms

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  • human gut
  • secondary metabolites
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  • accurate genome

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  • interactions occur
  • genome annotations
  • chemical reactions
  • complex microbiomes

  • microbiome chemistry
  • genomic tools
  • develop model
  • natural microbiomes
  • situ reaction

  • similar approach
  • functional biology
  • currently identify
  • microbiological research
  • microbiome metabolomes

  • microbiome behavior
  • moving forward
  • transforming microbiome
  • catalyze critical
  • engineering complex

  • individuals collectively
  • currently exist
  • characterizing secondary
  • ideas highlighted
  • unknown secondary


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