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Biomarkers of Neuroinflammation Proceedings of a Workshop (2018) / Chapter Skim
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1 Introduction and Overview
Pages 1-4

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From page 1...
... In particular, she cited the need for biomarkers that can be used as markers, not only of disease progression but of therapeutic efficacy as well, to make clinical trials and regulatory paths more straightforward. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases.
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From page 2...
... • Discuss the various definitions of neuroinflammation in use across the field, and the contribution of the peripheral and central nervous system's innate immune systems to normal brain function and disease pathophysiology. • Explore the state of the science of neuroinflammation biomarkers and research needed to enable the use of these biomarkers at the individual level.
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From page 3...
... Chapters 5 and 6 discuss neuroimaging biomarkers and fluid biomarkers of neuroinflammation, respectively. Chapter 7 offers the concluding thoughts of workshop participants on the challenges that still need to be addressed, and discusses ongoing efforts to build the collaborations to consolidate the data and expertise that will be needed to facilitate development and validation of neuroinflammatory biomarkers and to accelerate the development of new therapies.
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Key Terms

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  • acute versus

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  • tral nervous
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  • little agreement

  • proceedings summarize
  • chronic disease
  • innate immune
  • normal brain
  • brian campbell

  • ongoing efforts
  • developing biomarkers
  • research professor
  • translate increased
  • following proceedings

  • underlie neuroinflammation
  • current clinical
  • unique features
  • discusses ongoing
  • medicine convened

  • accelerate development
  • chronic settings
  • disease progression
  • individual presenters
  • governmental agencies


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