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Risk of Cardiac Rhythm Problems During Spaceflight
Pages 16-20

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From page 16...
... , and stress factors on bone loss was mentioned in the 2008 report, but no apparent progress or even consideration of these factors was obvious in the current evidence report. RISK OF CARDIAC RHYTHM PROBLEMS DURING SPACEFLIGHT The NASA evidence report Risk of Cardiac Rhythm Problems During Spaceflight was first published in 2009.
From page 17...
... In patients with coronary artery disease, the arrhythmogenic substrate is clear: a myocardial infarction or scar leading to focal areas of delayed conduction -- a necessary condition for a reentry current. For patients with apparently normal ventricular function, reentry is often not the mechanism of arrhythmia development.
From page 18...
... Thus, contemporary clinical decision making considers arrhythmia to be a "fact of life," stratifies the need to consider clinical intervention when hemodynamic function may be compromised (e.g., sustained ventricular tachycardia, ventricular fibrillation, severe bradyarrhythmias, or pulseless electrical activity) , and embraces a more holistic approach to screening for cardiovascular risk and disease with an emphasis on primary prevention.
From page 19...
... Does the Evidence Report Address Relevant Interactions Among Risks? The evidence report adequately presents human and animal spaceflight and ground-based experimental data in an attempt to link relevant interactions of arrhythmia factors, such as age, gender, fluid shifts, decreased cardiac mass (remodeling)
From page 20...
... ionizing radiation may be of concern, it is difficult to accept this paper as definitive "evidence." In fact, NASA has invested considerable resources in its space radiation program to determine whether in fact there are any cardiac risks associated with space radiation exposure since this is considered uncertain at space-relevant doses at this time. The background for this work is summarized in the NASA evidence report Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure (Patel et al., 2016)


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