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Frontiers of Engineering Reports on Leading-Edge Engineering from the 2018 Symposium (2019) / Chapter Skim
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Synthetic Biomarkers for Cancer Detection and Diagnosis - Ester J. Kwon
Pages 83-86

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
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From page 83...
... Exciting progress toward this goal includes activitybased probes to create "synthetic" biomarkers, methods to image metabolic activity of tumors, and devices for drug micro-dosing. Future goals are to coordinate the readouts from these diagnostic methods with molecular targeted therapeutics for a unified precision medicine approach for cancer treatment.
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From page 84...
... All these challenges are embodied in the National Institutes of Health Precision Medicine Initiative, an effort to understand "how a person's genetics, environment, and lifestyle can help determine the best approach to prevent or treat disease." CANCER BIOMARKERS CAN GUIDE CLINICAL CARE The timeline of cancer progression is complicated and includes risk assessment, screening, diagnosis of disease onset, response to treatment, and monitoring for relapse after treatment. Biomarkers can provide information about disease status and answer important questions such as, Who has cancer and how advanced is it?
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From page 85...
... Diagnostics with activity-based readouts are promising tools to stratify patients for these increasingly precise treatment regimes. The future of clinical management of cancer will include the integration of diagnostic information with molecularly targeted therapeutics.
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From page 86...
... Nature Biomedical Engineering 1:0054. Kwong GA, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos IA, Sverdlov DY, Liu SB, Warren AD, Popov Y, and 2 others.
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Key Terms

  • cancer treatment
  • targeted therapeutics
  • clinical management
  • ovarian cancer
  • cancer institute

  • clinical decisions
  • stratify patients
  • surgical navigation
  • clinical actions
  • guide clinical

  • molecularly targeted
  • protease activity
  • cancer diagnostics
  • treatment cancer
  • breast cancer

  • cancer trends
  • target cancer
  • engineered imaging
  • complications associated
  • drives challenges

  • treat disease
  • medicine initiative
  • technologies rely
  • particular tumor
  • psa reveals

  • administered synthetic
  • noisy biomarker
  • using methods
  • presymptomatic testing
  • increasingly precise


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