Brain Health Across the Life Span Proceedings of a Workshop (2020) / Chapter Skim
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2 Fundamentals of Brain Health and Resilience
2 Fundamentals of Brain Health and Resilience
Pages 5-10
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From page 5... ...
For example, in addition to addressing cognitive decline and other issues related to mental health and aging, outcomes could also include such targets as improving quality of life. (Damien Fair)
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From page 6... ...
MULTISCALE APPROACH FOR BRAIN HEALTH Akil explained that the multiscale approach to understanding brain health and functioning does not merely consider the brain in isolation. Rather, this approach takes into account individual, family, and social contexts as well as the elemental parts of the brain that are critical to its functioning, including neural circuits, neural cells, genes, and epigenetic modifications.
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From page 7... ...
Akil emphasized the importance of finding ways to compensate for these lifestyle changes by helping human brains adapt in positive ways. She posited that the huge global burden of brain disorders is a manifestation of this disconnection between the way people live today and the ways human brains have adapted.
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From page 8... ...
The shaping of brain health begins very early in the life span -- perhaps even earlier when accounting for intergenerational influences -- and this underscores the need to consider individual differences in brain health trajectories. These include biological embedding of the social environment as well as the potential for particular kinds of interventions to promote positive plasticity, depending on an individual's life history and exposures throughout
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From page 9... ...
This underscores the need to find ways to counterbalance the epigenetic intergenerational effect. Damien Fair, associate professor of behavioral neuroscience, associate professor of psychiatry, and associate scientist at the Advanced Imaging Research Center at the Oregon Health & Science University, remarked that efforts to characterize brain health should be framed by specifically defined outcomes and endpoints that are being targeted.
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From page 10... ...
Akil urged the participants to consider ways to understand and quantify resilience on a biological level within and across individuals. One strategy might be to study the brain, behavior, biology, and contexts of people who report feeling good about their life despite major adversities, like being paralyzed or having a sick child.
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