Foundational Research Gaps and Future Directions for Digital Twins (2024) / Chapter Skim
Currently Skimming:
Appendix D: Opportunities and Challenges for Digital Twins in Biomedical Research: Proceedings of a Workshop - in Brief
Appendix D: Opportunities and Challenges for Digital Twins in Biomedical Research: Proceedings of a Workshop - in Brief
Pages 149-162
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 149... ...
D Opportunities and Challenges for Digital Twins in Biomedical Research: Proceedings of a Workshop -- in Brief Opportunities and Challenges for Digital Twins in Biomedical Research: Proceedings of a Workshop -- in Brief (National Academies of Sciences, Engineering, and Medicine, The National Academies Press, Washington, DC, 2023) is reprinted here in its entirety.
|
From page 150... ...
Given across scales, and implementation issues surrounding the multiscale nature of biological structures and their data privacy in DTs. The first in a three-part series, this environment, biomedical DTs can represent molecules, information-gathering workshop will inform a National cells, tissues, organs, systems, patients, and populations Academies consensus study on research gaps and future and can include aspects from across the modeling and directions to advance the mathematical, statistical, and simulation ecosystem.
|
From page 151... ...
creating appropriate experimental data (often from mice or tissue cultures) is funding models for individual medical DT projects from frequently used in building the computational models for conception to prototype, and for larger infrastructure medical DTs.
|
From page 152... ...
The Systems Biology Markup Language, which applies to differential equation models, is an established standard EMBRACING OR SIMPLIFYING COMPLEXITY IN DIGITAL TWINS in the biomedical community; however, he noted During the first panel, workshop participants heard brief that much more work remains in the development of presentations on DTs at the cellular and molecular scale standards overall for medical DTs to be used at scale. from the perspectives of pharmaceutical development, clinical practice, and research.
|
From page 153... ...
By introducing other across multiple cell types in mouse models through known chemical aspects and probing elastic properties, 3 The Swedish Digital Twin Consortium website is https://sdtc.se, accessed February 27, 2023. they could visualize the process not being captured JUNE 2023 | 4
|
From page 154... ...
SPATIAL AND TEMPORAL CONSIDERATIONS IN DIGITAL TWINS Amaro explained that many indirect experiments can During the second panel, workshop participants heard validate emerging predictions. When hypotheses and brief presentations on DTs at the organ, tumor, and results can be interrogated and replicated by other microenvironment scale in the areas of computational JUNE 2023 | 5
|
From page 155... ...
a patient is unlikely to be cured with only one therapy, Discussion he remarked that these models should be updated Incorporating questions from workshop participants, continually during treatment. To begin to address these Caroline Chung, MD Anderson Cancer Center, challenges, techniques from other fields could be applied moderated a discussion among both speakers and two such as optimal control theory, reduced order modeling, experts in intelligent systems engineering and applied uncertainty quantification, and data assimilation.
|
From page 156... ...
Self-driving cars provide an missing from real-world training data, he asserted that important lesson for the future of medical DTs in terms combining mechanistic and data-driven approaches of the value of bootstrapping, he continued. He suggested could lead to the development of more reliable models.
|
From page 157... ...
estimating the treatment effect from a completed study using a linear model while Badano explained that manufacturers are expected to adjusting for the control outcomes predicted by the establish the safety and effectiveness of their devices prognostic model. He emphasized that the context of use for intended populations -- usually via clinical trials.
|
From page 158... ...
Badano explained that simulation enables continuous updates, and recalibration for DTs. Coleman exploration of patients at the edge of the distribution, stressed that context matters: for a clinical trial related which offers another avenue to better understand to a neuropsychiatric condition, the DT should be able failure modes.
|
From page 159... ...
Other project goals include clinical trials with explanations to help build better identifying research challenges and enabling predictive models. infrastructure, developing use cases, and driving large-scale adoption, all of which require advances in CONNECTING DATA AND MODELS ACROSS SCALES technology; user experience; ethical, legal, social, and During the fourth panel, workshop participants heard regulatory frameworks; and sustainability.
|
From page 160... ...
proposed standardizing the interoperability layers instead of standardizing the data or the models themselves. An Qualters asked about the benefits of aggregating data observed that such issues of composability are an active for medical DTs and whether additional privacy issues research gap.
|
From page 161... ...
Price responded that although questions will arise about appropriate data and model medical DTs are not yet deployed often in the real world, access. guidance is based on the data collected at the molecular scale, connected with patient outcome data.
|
From page 162... ...
COMMITTEE ON FOUNDATIONAL RESEARCH GAPS AND FUTURE DIRECTIONS FOR DIGITAL TWINS Karen E Willcox (Chair)
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.