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Toxicity Testing Strategies to Determine Needs and Priorities (1984) / Chapter Skim
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INTRODUCTION
Pages 19-22

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From page 19...
... In recent decades, there has been widespread concern that synthetic chemical substances -- increasing in number and concentrations -- and natural substances may adversely affect human health. In response to the concern, such agencies as the Environmental Protection Agency, the Consumer Product Safety Commission, the Occupational Safety and Health Administration, the Food and Drug Administration, and the Department of Agriculture began to monitor the use of chemicals.
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From page 20...
... It can be used for the prevention of chemically induced disease and for otherwise protecting the health of the American people. The NTP Executive Committee provides linkage between DHHS research agencies and federal regulatory agencies to ensure that toxicologic research and test development under the aegis of NTP are responsive to the needs of those agencies and to the needs of the public.
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From page 21...
... (3) They established criteria by which to judge the quality of individual toxicity studies and of toxicity data bases on individual substances in the subsample, to determine their suitability for assessing hazards to human health.
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From page 22...
... It then designed and refined a model for the selection of methods believed to be important in setting priorities, elucidated performance characteristics at various stages of the priority-setting system, indicated how they may be applied, and determined the relative roles of expert judgment and the more mechanized aspect of the priority-setting approach. In this final report, the Committee on Sampling Strategies and the Committee on Toxicity Data Elements describe in detail the criteria they used to determine the status of testing quality and their collective judgment on the testing needs for substances in the select universe.
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Key Terms

  • national toxicology
  • data elements
  • sampling strategies
  • toxicology program
  • potentially toxic

  • commonly called
  • priority mechanisms
  • toxic chemicals
  • control act
  • setting priorities

  • toxic substances
  • human exposure
  • select universe
  • substances control
  • toxicity information

  • entitled strategies
  • product safety
  • chemical substances
  • anticipated human
  • committee provides

  • nrc transmitted
  • developing sound
  • formulated operating
  • synthetic chemical
  • assessing hazards

  • substances inventory
  • information requires
  • strategies selected
  • appropriate information
  • performance criteria


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