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Toxicity Testing Strategies to Determine Needs and Priorities (1984) / Chapter Skim
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PART 2: SETTING PRIORITIES FOR TOXICITY TESTING
Pages 199-204

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Select key terms on the right to highlight them within pages of the chapter.


From page 199...
... BRIEFLY FOLLOWING A CHEMICAL THROUGH AN ILLUSTRATIVE SYSTEM Stage 1 Stage 2 Stage 3 Stage 4 4. DETAILED DESCRIPTION OF THE OPERATION OF AN ILLUSTRATIVE SYSTEM Introduction Elements of Design Goal Universe Assessment Structure Rules for Selection Design Parameters Stage 1 Exposure Data Elements Toxicity Data Elements Selection Rules Stage 2 Exposure Data Elements Toxicity Data Elements Selection Rules 199 Page 205 207 208 208 210 213 215 218 221 222 222 222 223 226 227 227 232 234 235 237 237 237 237 237 238 238 238 239 239 240 243 255 258 258 267 270
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From page 200...
... Tests Random Sampling 6.
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From page 201...
... Selected Sources of Toxicity Information by Effect 14. Hypothetical Estimates of Probability Distributions of Carcinogenic Potency as Generated in Stage 2, in Relation to Assigned Degree of Concern about Carcinogenicity and.Degree of Confidence in Assignment 201 245 256 257 257 260 264 265 267 268 271
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From page 202...
... Predictive Accuracy of Several Short-Term Tier Testing Regimens 21. Chemicals Analyzed by Short-Term Tests (International Collaborative Study)
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From page 203...
... Be Decision rules used in processing example chemical bispbenol A
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From page 204...
... Page Appendix A Review of Selected Priority-Setting Systems 301 Appendix B Mathematical Modeling of the Priority Setting Process and Resulting Decision Rules 319 Appendix C Expert Judgment and the Treatment of Uncertainty 347 Appendix D The Analysis of Structure-Activity Relation ships in Selecting Potentially Toxic Compounds for Testing 355 Appendix E Costs of Misclassification 363 Appendix F Differences Between Part 1 and Part 2 381 204
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Key Terms

  • probability distributions
  • hypothetical estimates
  • carcinogenic potency
  • exposure data
  • elements toxicity

  • assigned degree
  • selection rules
  • toxicity data
  • elements selection
  • decision rules

  • rules stage
  • exposure generated
  • estimated proportions
  • rtecs code
  • universe assessment

  • example chemical
  • sample checklist
  • design goal
  • estimated degrees
  • assessment structure

  • reviewing dossier
  • tier testing
  • structure rules
  • exposure assessment
  • parameters stage

  • detailed description
  • chemical bispbenol
  • goal universe
  • predictive accuracy
  • random sampling


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