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Causes and Effects of Stratospheric Ozone Reduction An Update (1982) / Chapter Skim
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G THE ASSOCIATION OF DNA DAMAGE WITH CANCER-INITIATING EVENTS
Pages 331-332

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From page 331...
... The cells of individuals with this disease are defective in one or more mechanisms that repair ultraviolet damage to DNA. Defects in repair are associated with a 103- to 104-fold higher skin cancer prevalence in xeroderma pigmentosum individuals than in the average population.
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From page 332...
... If, however, visible light exposure follows the ultraviolet exposure, that is to say, the cells are subjected to photoreactivation, no tumors develop. Since photoreactivation is diagnostic for pyrimidine dimers (Chapter 3)
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Key Terms

  • tumors develop
  • xeroderma pigmentosum
  • neoplastic transformation
  • skin cancer
  • cancer prevalence

  • carcinogenic test
  • light exposure
  • poecilia formosa
  • liver carcinogenicity
  • species poecilia

  • animal carcinogenic
  • action spectrum
  • inactive mutagenic
  • mammalian cells
  • activating enzymes

  • ultraviolet exposure
  • visible light
  • average population
  • thyroid tumors
  • animals contain

  • exposure follows
  • affecting dna
  • pigmentosum individuals
  • disease xeroderma
  • active metabolites

  • similar association
  • activating inactive
  • pyrimidine dimers
  • cellular macromolecules
  • tumor production


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