Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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o-Dichlorobenzene
o-Dichlorobenzene
Pages 22-25
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From page 22... ...
The basic conclusions and recommendations contained in the 1977 Dnnking Water and Health report remain valid, and mutagenicity and teratogenicity data are still needed. Bioassays for carcinogenesis fulfill the need for some data; however, well-designed studies of subchronic exposures should be conducted to identify species differences in potential hepatotoxicity and to learn which effects should be used as a basis for establishing limits in drinking water.
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From page 23... ...
Female Wistar rats dosed orally with o-dichlorobenzene at a level of 250 mg/kg for 3 days had an increase in liver weights and microsomal protein content and enhanced aminopyrine demethylase activity in the liver (Ariyoshi et al., 1975~. O-Dichlorobenzene injected intraperitoneally into male Sprague-Dawley rats produced centrilobular necrosis that was enhanced by prior administration of phenobarbital (Reid et al., 1973)
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From page 24... ...
Chronic Effects Repeated oral doses as high as 376 mg/kg given to female rats for 192 days produced a moderate increase in liver weights and a slight increase in kidney weights. After 7-hour inhalation exposures administered 5 days/week for 6 to 7 months at levels of 49 or 93 ppm (271 or 513 mg/m3)
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From page 25... ...
METAB OLISM The metabolism of p-dichlorobenzene was extensively studied in rats following repeated inhalation, oral, or subcutaneous doses (Hawkins et al., 1980~. After these exposures, residues detected by ]
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