Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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1,2-Dichloroethylene (cis and trans)
1,2-Dichloroethylene (cis and trans)
Pages 40-43
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From page 40... ...
If present in drinking water, 1,1-dichloroethylene would be rapidly and completely absorbed. At the low levels expected to be present, dose-dependent kinetics involving saturation of the metabolic pathways would not occur, so that nearly all of the compound would undergo metabolic conversion.
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From page 41... ...
At 1,500 mg/kg, the bans isomer caused only a decrease in liver tyrosine transaminase, whereas the cis isomer caused decreases in liver glucose-6phosphatase, liver tyrosine transaminase, and plasma glutamic-pyruvic transaminase (alanine aminotransferase) , along with an increase in liver alkaline phosphatase.
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From page 42... ...
Cardiac muscle damage was observed at 3,000 ppm. In an additional study, female rats exposed by inhalation to 200 ppm concentrations of both the cis and bans isomers for ~ hours exhibited increases in hexobarbital-induced sleeping times and zoxazolamine-induced paralysis times and decreased metabolism of aminopyrine (Freundt and Macholz, 19781.
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From page 43... ...
Long-term studies, especially those involving oral administration, are needed before a chronic SNARL can be determined. In view of its structural similarity to vinyl chloride, a carcinogenesis bioassay is desirable.
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