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Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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Dichloromethane
Pages 43-46

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From page 43...
... In addition, studies are needed to determine the teratogenic and reproductive effects of these isomers, and additional investigations should be conducted to examine their mutagenic properties in mammalian cells. DICHLOROMETHANE methylene chloride; methane, dichIor~ CAS No.
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From page 44...
... The investigators did not specify whether or not the response was obtained in the presence and/or absence of a mammalian metabolic activation system. When 104 mM and 157 mM concentrations were incubated in suspension with logarithmically growing Saccharomyces cerevisiae D7 cells for 1 hour at 37°C, dichloromethane also induced gene mutation, recombination, and mitotic gene conversion.
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From page 45...
... The National Toxicology Program Technical Review Subcommittee, which evaluated this bioassay, concluded that there may have been excessive mortality due to gavage errors and also that the maximum tolerated dose may have been exceeded. Teratogenicity Hardin and Manson (1980)
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From page 46...
... , but it can form salts with inorganic and organic bases, some of which are more soluble in water. METAB OLI SM Dinoseb is believed to enhance metabolic activity by uncoupling oxidative phosphorylation and disrupting adenosine triphosphate synthesis (Brody, 1955)
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Key Terms

  • dna synthesis
  • drinking water
  • volatile mutagenic
  • mammalian metabolic
  • rat liver

  • primary human
  • liver metabolic
  • carboxyhemoglobin levels
  • human fibroblasts
  • saturation kinetics

  • national toxicology
  • exogenous metabolic
  • metab oli
  • toxicology program
  • cultured primary

  • limit value
  • mammalian cells
  • cis nor
  • oral administration
  • six paint

  • sister chromatic
  • measured blood
  • additional investigations
  • varnish removers
  • neoplastic nodules

  • volunteers exposed
  • orally administered
  • mitotic gene
  • exogenous mammalian
  • colleagues found


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