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Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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Dinoseb
Pages 46-49

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From page 46...
... , but it can form salts with inorganic and organic bases, some of which are more soluble in water. METAB OLI SM Dinoseb is believed to enhance metabolic activity by uncoupling oxidative phosphorylation and disrupting adenosine triphosphate synthesis (Brody, 1955)
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From page 47...
... Dinoseb added to the diet of rats resulted in food refusal at approximately 56.7 mg/kg. A level of about 22.7 mg/kg diet caused a small but significant decrease in growth rate and a slight elevation in blood urea nitrogen (BUN)
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From page 48...
... The following malformations were observed in the surviving embryos: skeletal defects, cleft palate, hydrocephalus, and adrenal agenesis. Oral administration of 20 or 32 mg/kg/day produced no gross or soft tissue defects, but some maternal toxicity was reported.
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From page 49...
... An uncertainty factor of 1,000 is used because this study was only of 6 months duration. Assuming that a 70-kg human consumes 2 liters of water daily and that 20~o of the intake is derived from water, one may calculate the SNARL as: 5.6 mg/kg X 2 X 70 kg = 0.039 mg/liter, or 39 /liter Limited human data indicate that high exposure to dinoseb can result in a variety of physical and psychological symptoms.
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Key Terms

  • data indicate
  • renal function
  • oral exposures
  • dinoseb intoxication
  • health aspects

  • dinoseb added
  • male rat
  • lactic dehydrogenase
  • dinoseb elicited
  • oral administration

  • blood alkaline
  • postnatal day
  • maternal toxicity
  • soft tissue
  • recommendations suggested

  • mitotic gene
  • following oral
  • uncertainties involving
  • estimated oral
  • strongly inhibited

  • tractor driver
  • fetotoxicity observed
  • postnatal renal
  • kinetics exhibited
  • lifetime exposures

  • studied postnatal
  • concentrations ranging
  • uncoupling oxidative
  • guinea pig
  • following malformations


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