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Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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Methomyl
Pages 57-60

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From page 57...
... It binds reversibly with blood cholinesterase, which, in combination with its rapid rate of metabolism, may explain its high acute oral toxicity and much lower chronic oral toxicity (Kaplan and Sherman, 1977~. HEALTH ASPECTS Observations in Humans A growing number of case histories have indicated that methomyl is highly toxic to humans following acute exposure, frequently requiring hospitalization as a result of blurred vision (Liddle et al., 1979; Morse et al., 1979; Smith, 1977)
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From page 58...
... (1979) reported that this interaction produced decreased growth, an increased ratio of adrenal gland weight to body weight in both sexes, and several sex-specific changes, including increased hepatic triglyceride and free fatty acid levels in males and increased relative weight of kidneys and fasting glucose levels in females.
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From page 59...
... A three-generation reproduction study in rats showed that methomyl did not have any adverse effects on various reproductive performance indices that could be attributed to feeding dietary levels of 50 and 100 ppm (Kaplan and Sherman, 1977~. After reviewing the data, the committee concluded that methomyl is not teratogenic to rats or white rabbits.
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From page 60...
... METAB OLISM Picloram is rapidly absorbed from the gastrointestinal tract and is excreted virtually unchanged in the urine and feces of male Fischer 344 rats within 48 hours (Nolan et al., 1980~. Following a 10 mg/kg ~4C-picloram intravenous dose, the isotope was cleared biphasically and excreted in the urine.
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Key Terms

  • excretion resulted
  • adequate diet
  • histopathological changes
  • dietary levels
  • nutritionally adequate

  • oral toxicity
  • hamster cell
  • chronic oral
  • body weight
  • cell assay

  • reproductive performance
  • health aspects
  • including increased
  • anticholinesterase compounds
  • urinary excretion

  • urinary metabolites
  • methomyl induced
  • glucose levels
  • chronic animal
  • decreased weight

  • water daily
  • mice fed
  • adrenal gland
  • increased hepatic
  • acute oral

  • chronic effects
  • highly toxic
  • rapidly absorbed
  • plasma levels
  • olism picloram


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