Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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Picloram
Picloram
Pages 60-63
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From page 60... ...
METAB OLISM Picloram is rapidly absorbed from the gastrointestinal tract and is excreted virtually unchanged in the urine and feces of male Fischer 344 rats within 48 hours (Nolan et al., 1980~. Following a 10 mg/kg ~4C-picloram intravenous dose, the isotope was cleared biphasically and excreted in the urine.
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From page 61... ...
Chronic Effects Lifetime daily exposure of rats and dogs to diets containing 150 mg/kg bw doses of picloram resulted in no observable gross or microscopic signs of toxicity. In multigeneration studies conducted in rats at dietary concentrations up to 3,000 ppm, there was no evidence of adverse effects at the highest level tested (Johnson, 1971~.
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From page 62... ...
Teratogenicity Multigeneration studies, in which rats were exposed to picloram from gestation through reproductive cycles to levels as high as 3,000 ppm diet, produced no evidence of effects on fertility, gestation, viability of pups, lactation, or skeletal development. Pregnant rats receiving doses of 1,000 mg/kg/day during organogenesis were normal, but there was a slight increase in embryo resorption.
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From page 63... ...
83-794 OCH3 CH3O ~r~ CH2 H , Car H CH3 In the form of ground derris root, rotenone has been used as a nonpersistent insecticide to control pests on plants and animals and as a fish poison to manage or to eliminate undesirable species in reservoirs, lakes, and streams (Fukami et al., 1967~. First isolated in 1895, world consumption is
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