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Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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Tetrachloroethylene
Pages 70-74

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From page 70...
... , and assuming that a 70-kg human consumes 2 liters of water daily and that 20% of intake is provided by the water, one may calculate the SNARL as: 2 mg/kg X 70 kg X 0.2 14 /li 2 liters X 1,000 Because results of acute toxicity studies have been variable, additional studies with the purified chemical, with several animal species, and with several routes of administration appear warranted. Additional teratological evaluation should also be considered, assuming that humans may be exposed to the chemical through drinking water.
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From page 71...
... observations of relative hepatic macromolecular binding of tetrachloroethylene metabolites indicated that the metabolism of tetrachloroethylene proceeds at a more rapid rate and to a greater extent in mice than in rats. In vitro studies with rat hepatic microsomes conducted by Costa and lvanetich (1980)
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From page 72...
... Although body weight was not affected by treatment, relative liver weight was significantly increased in mice at all except the lowest doses and in rats at 1,000 mg/kg. Histological examination revealed hepatic changes only in the rats receiving 1,000 ma/ kg/day, and these were considered minimal.
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From page 73...
... The limited data indicate that tetrachloroethylene is not teratogenic in mice and rats. CONCLUSIONS AND RECOMMENDATIONS Information made available since the last review of tetrachloroethylene in Drinking Water and Health (National Research Council, 1980)
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From page 74...
... There also continues to be a need for further research to elucidate mechanisms of tetrachloroethylene toxicity and species differences in response to this compound. Data from carefully designed subchronic studies to determine effect and no-effect doses would permit much better estimation of the risk associated with low-level exposure of humans.
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Key Terms

  • third volume
  • metabolism studies
  • chlorinated ethylenes
  • workers exposed
  • national toxicology

  • information contained
  • toxicology program
  • rapid rate
  • following material
  • negative results

  • risk associated
  • unresolved pending
  • yielded positive
  • designed subchronic
  • water daily

  • hepatic microsomes
  • maximal sublethal
  • sister chromatic
  • consequently rapid
  • human consumes

  • following inhalation
  • histological examination
  • methyl chloroform
  • atmospheric concentrations
  • rats receiving

  • teratological evaluation
  • lobular pattern
  • consecutive daily
  • metabolism following
  • pharmacokinetic model


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