Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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Trichloroethylene
Trichloroethylene
Pages 79-85
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From page 79... ...
In both rats and mice, the induction of hepatic microsomal enzymes led to a greater degree of Trichloroethylene bioactivation and increasing quantities of trichloroethylene-related materials covalently bound not only to hemes and cytochromes but also to various macromolecules, proteins, lipids, and DNA (Pessayre et al., 1980; Sipes and Gandolfi, 1980; Stott et al., 1982~. These studies extend and confirm previously postulated mechanisms of Trichloroethylene toxicity.
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From page 80... ...
as a basis for concluding that humans metabolize approximately 20 times less trichloroethylene than rats, on a weight basis. Since the metabolism of trichloroethylene is an important factor in its toxicity, one must view toxicity data cautiously when making interspecies comparisons.
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From page 81... ...
The results of this study lend further support to the conclusion that trichloroethylene is not toxic in humans at exposure levels > 100 ppm (535 mg/m3~. Observations in Other Species Acute Effects The committee found no new reports that would amplify or extend the data cited in the previous reviews.
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From page 82... ...
Positive findings of carcinogenicity in B6C3F~ mice in a previous study by the National Cancer Institute (1976) were discussed in the first and third volumes of Drinking Water and Health (National Research Council, 1977, pp.
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From page 83... ...
Using the data from the study by the National Toxicology Program (1982a) , the committee estimated the lifetime risk and upper 95~o confidence estimate of lifetime risk to humans after a daily consumption of TABLE Il-8 Tumor Incidence in Trichloroethylene-Exposed Micea Tumor Animals Sex Site Dose, Tumor mg/lcg/day Rates B6C3F' mouse Male Liver B6C3F' mouse Female Liver O
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From page 84... ...
TABLE II-9 Carcinogenic Risk Estimates for Trichloroethylenea Upper 95~o Confidence Esti Estimated Human mate of Lifetime Cancer Animal Sex Lifetime Riskb Risk per ~g/liter B6C3FI mouse Male 3.77 x 10-7 5.48 X 10-7 B6C3F' mouse Female 6.84 X 10-8 1.12 x 10-7 a Based on data from thc National To~cicology Program, 1982a. bAssuming a daily consumption of I liter of watcr containing the compound in a concentration of 1 ~B/ liter.
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From page 85... ...
75 014 H2C = CHCl Vinyl chloride was evaluated in the first volume of Dunking Water and Health (National Research Council, 1977, pp.
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