Understanding and Preventing Violence, Volume 2 Biobehavioral Influences (1994) / Chapter Skim
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Pages 257-260
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From page 257... ...
NeuropharmacoJogic Manipulations of 5-HT in Animals Impairments of brain 5-HT systems by removing the dietary precursor t-tryptophan, blocking the synthetic enzyme tryptophan hydroxylase, depleting the 5-HT vesicular storage, or cytotoxically or electrolytically destroying serotonin neurons lead mostly to suppression of attack and threat behavior by isolated mice Isee Table 3, section B; e.g., PoschIova et al., 1975; Rolinski, 1975; Eichelman, 1981; Payne et al., 1984; Svare and Mann, 1983; lent and Thurmond, 19851. However, pharmacologic manipulations with opposite biochemical effects such as tryptophan Toads, administration of the precursor 5-HTP ;5-hydroxytryptophan)
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From page 258... ...
(5) Some carnivores such as cats, ferrets, or grasshopper mice are actually imnnired in their killing behavior when 5-HT synthesis is blocked r ~ _= ~ ~ ~ .
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From page 259... ...
The 5-HT2 receptor antagonist ketanserin reduces attack and threat behavior by isolated resident mice and rats effectively, although with limited behavioral specificity Haney and Miczek, 1989; Olivier et al., 1989~. Initial data on the effects of experimental 5-HT3 receptor antagonists show no specific effects on aggressive behavior in isolated mice or lactating female rats {Mos etal.,1990~.
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From page 260... ...
Preliminary data from vervet monkeys also suggested higher 5-HIAA in CSF of dominant group members than in subordinates Raleigh et al., 19831. Inconsistent and unreliable correlations between CSF 5-HIAA and aggressive behavior were found in several extensive series of studies in talapoin, rhesus macaque, and squirrel monkeys ;Yodyingyuad et al., 1985; Kraemer, 1985; Green et al., personal communication)
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