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Understanding and Preventing Violence, Volume 2 Biobehavioral Influences (1994) / Chapter Skim
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Pages 261-262

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From page 261...
... A series of recent studies in squirrel monkeys and rhesus monkeys with chronic administration of the hallucinogenic "designer" amphetamine derivatives "ecstasy" and "eve," which have profound cytotoxic actions on brain 5-HT and markedly Tower CSF 5-HIAA, has reveaTed no evidence for increased violent activity E.g., Ricaurte et al., 1985, 1989; Molliver 19871. To interpret the significance of CSF 5-HIAA data, the relative contribution of anatomically distinctive pools of 5-HT neurons in different brain regions to CSF metabolite levels needs to be determined.
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From page 262...
... Alterations in 5-HT activity have also been related to aggressive behaviors by resorting to measurements of blood chemistry {Table 3, section Cal. These peripheral indices include whole blood levels, plasma tryptophan/neutral amino acid ratio, and bincling of tritiated imipramine to blood platelets.
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Key Terms

  • aggressive behavior
  • mentally retarded
  • chronic administration
  • retarded patients
  • squirrel monkeys

  • rhesus monkeys
  • human aggression
  • brain regions
  • aggressive behaviors
  • amino acid

  • blood platelets


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