Understanding and Preventing Violence, Volume 2 Biobehavioral Influences (1994) / Chapter Skim
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Pages 268-270
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From page 268... ...
there is no universally effective antiviolence drug, but rather specific agents exert efficacious antiaggressive effects in specific types of violent individuals; ~2) acute and Tong-term management are achieved with different types of agents; and {3~ the multiply interacting neurochemical systems mediating aggressive and violent acts offer several targets for pharmacologic interventions.
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From page 269... ...
Defensive reactions to brain stimulation or painful environmental events have proven relatively immune to the suppressive effects of neuroleptic drugs {see Table 7A; e.g., Dubinsky and Goldberg, 1 9 7 1; Andy and Velamati, 1 9 78; Tedeschi et al., 1 969 J Studies in mice and rats point to potent modulatory effects on escape and defensive responses by treatment with D2 receptor antagonists {Silverman, 1965a,bJ and agonists {Puglisi-Allegra and Cabib, 1988; Cabib and Puglisi-Allegra, 1989 J
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From page 270... ...
Aggressive and destructive behavior in children, usually diagnosed with conduct disorder, minimal brain damage, or mental retardation, has been successfully decreased with thioridazine and similar piperidylalky~phenothiazines {see Table 7B; e.g., Alderton and Hoddinott, 1964; ATexandris and Lundell, 1968J. In addition to the reduction in aggressive behavior, these neuroleptics also had pronounced effects on the level of motor activity, not only decreasing hyperactivity, but often lengthening reaction times and sometimes leading to apathy and drowsiness {e.g., Shaw et al., 1963; ATexandris ant]
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