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Health Effects of Exposure to Radon Time for Reassessment? (1994) / Chapter Skim
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3 Exposure-Dose Relations
Pages 43-50

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
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From page 43...
... The unattached fraction of radon progeny i.e., atoms of the radon progeny not attached to dust particles- is typically higher in homes. Ventilation is probably greater for working miners than for persons indoors in homes, although patterns of oral and nasal breathing have not been well characterized for those groups.
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From page 44...
... Uncertainties arising from dosime~c differences between exposures in the two settings can be characterized by comparing the relationships between exposure and dose. Before the BEIR IV report (National Research Council, 1988)
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From page 45...
... Furthermore, although the panel followed He conventional approach of lung dosimetnc modeling to estimate K, the predictions of the models could not be validated in biologic systems. The panel recommended more research on acEvity-weighted size distributions of radon progeny in various settings, including mines and buildings; on breathing by humans under diverse circumstances; on deposition patterns of submicrometer particles in the upper anways and lung; on hydroscopic growth of particles in He respiratory tract; on the physical behavior of progeny deposited In mucus; and on the cells at risk for transformabon to lung cancer.
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From page 47...
... The proliferative potential of epithelial cell populalions has been examined to gain insight into the target cells for malignant transforrnabon. An assumption underlying interpretation of Dose experiments is Mat cells Cat show proliferative capacity are also Me target cells for carcinogenesis which is not necessarily the case.
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From page 48...
... , where the basal cell preparation produced an epi~elium of basal and ciliated cells arid the secretory cells yielded secretory cells as well as basal and ciliated cells. Similarly, using flow cytometry to obtain He two cell populations and growth ~ cell culture to assess proliferative potential, Johnson and colleagues (John son et al., 1990)
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From page 49...
... Win He cessation of conventional underground uranium mining in the United States, it is no longer possible to make relevant activitysize distribution measurements in this country. Data could be gathered In Canada and over countries where underground uranium mining continues, but He relevance of such contemporary information to the historical cohorts would be uncertain.
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From page 50...
... However, Be committee recommends Cat a Phase Research Council committee · Use noninvasive mesons for monitoring ventilation to obtain additional information that is relevant to radon dosimetry and an improved model. · Continue to evaluate infonnadon on the cells at risk for radoninduced lung cancer.
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Key Terms

  • radon progeny
  • proliferative capacity
  • proliferative potential
  • rat tracheal
  • lung cancer

  • tracheal epithelium
  • target cells
  • lung dosimetry
  • deposition patterns
  • underground miners

  • radon panel
  • respiratory tract
  • uncertainties related
  • basal cell
  • cell culture

  • underground uranium
  • flow cytometry
  • human lung
  • cell populations
  • risk estimates

  • ciliated cells
  • basal cells
  • uranium mining
  • indoor environments
  • complete understanding

  • sources typically
  • size distributions
  • inherent limitations
  • relatively sophisticated
  • historical cohorts


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