Health Effects of Exposure to Radon Time for Reassessment? (1994) / Chapter Skim
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Executive Summary
Executive Summary
Pages 1-10
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This report was prepared by He Com~t~e on Heal Risks of Exposure to Radon: BEIR VI in He Board on Radiation Effects Research (BRER) of the Research Council's Commission on Life Sciences, which was charged, in Phase I, Woo ga~enng evidence Hat had accumulated on radon and lung cancer since two prior reviews by BRER committees and determining whether He new information justified a comprehensive study which would constitute Phase H
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· Further information relevant to the dosimetry of radon in mines and homes. This information emerges from new ins~umentation for field measurements of the concentration and activity-size distributions of radon progeny developed in the laboratory of Philip Hopke and the application of noninvasive methods for monitoring veneration In He field by Jonathan Sarnet and others.
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Evaluation of new information concerning the molecular changes occurring In radon-induced cancer and the correlation of these changes to the nature of radon-induced chromosomal aberrations, mutations, and DNA lesions should be informative as to the mechanisms involved In He induction of lung cancer and should be useful in the development of a risk model. Furler key uncertainties in the previous estimates arid models might be reduced and should be considered formally in a Phase ~ study.
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study could Critique Be recently completed pooled analyses of ~ ~ cohorts and whatever new risk models emerge from them and use the database to suggest additional analyses. · Mode} the pooled data with emphasis placed on biologically driven modeling.
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With respect to the analysis of data from series of residential exposure, the committee modified certain proposed tasks so that a Phase · study could also · Critically review studies arid comment on their strengths and weaknesses and their current and future roles in risk assessment. · If EPA and BRER have agreed that it is feasible, update the assumptions and estimates in the Research Council report that compared miner and home dosimetry, focusing on recent data on such physical and biological factors as aerosol size distribution, ultrafine fraction, equilibrium fraction, and hygroscopicity and deposition of radon daughters in the respiratory tract.
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committee include at least 12 members. The expertise that should be represented includes radiation biology, biophysics, aerosol science, cellular and molecular biology, epidemiology, biostatisiics, carcinogenesis, lung pathology, risk assessment (including uncertainty analysis)
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HEALTH EFFECTS OF EXPOSURE TO RADON: [dime for Reassessment?
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