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Pages 203-204

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From page 203...
... Chemical Ecology: A View from the Pharmaceutical Industry /195 novel functions rather than destroy useful ones are likely to have bee evolutionarily selected (1071. For example, after duplication of a serine protease gene, a functional serine protease that is specific for a new substrate arises through mutations that alter amino acids located in those regions of the protease that determine substrate specificity (3081.
From page 204...
... 196 / Lynn Helena Caporale such a study helps to define a three-dimensional array that provides successful ligands for the target. A scaffold that fits the target may exist in nature fortuitously, having a different function but just the right shape to interact with our target, and/or may have evolved when nature confronted the same structural problem as that before us.

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