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Xenotransplantation Science, Ethics, and Public Policy (1996) / Chapter Skim
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Appendix C-Immunosuppression in Allotransplantation
Pages 123-126

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From page 123...
... These medications attenuate or abolish the immune reactions responsible for rejection. The new generation of immunosuppressive drugs has significantly prolonged graft survival of kidneys, livers, hearts, and heart-lungs, among others.
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From page 124...
... The first available anticytokine was cyclosporine, which has twice the effectiveness of azathioprine in extending kidney allograft survival. Cyclosporine inhibits Tcells from producing cytokines, such as interleukin-2, which are the intercellular signals that lead to stimulation of other immune cells to attack the graft.
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From page 125...
... All antibody medications derived from animal cell lines have the potential to elicit host sensitization because of foreign epitopes. Recent advances in molecular biology have enabled scientists to "humanize" animal antibodies that could result in no, or .
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From page 126...
... These goals underlie research on the identification of new, less toxic immunosuppressives.
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Key Terms

  • ideal immunosuppressive
  • host sensitization
  • graft rejection
  • clinical trials
  • host immune

  • acquired sensitization
  • immunosuppressive drug
  • cytoplasmic protein
  • immunosuppressive drugs
  • blocking production

  • treated successfully
  • block cell
  • effectively treats
  • immunosuppressive agent
  • human clinical

  • transplant deaths
  • robust immune
  • medications attenuate
  • drug discovery
  • animal cell

  • selective immunosuppressives
  • intracellular signal
  • xenotransplant research
  • immune cells
  • allograft survival

  • particular foreign
  • intercellular signals
  • key feature
  • significantly prolonged
  • available anticytokine


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