Regulating Pesticides (1980) / Chapter Skim
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Appendix B: The Carcinogenic Activity Indicator
Appendix B: The Carcinogenic Activity Indicator
Pages 253-257
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From page 253... ...
The more the study parameters characterizing CA' values for different compounds agree, the more likely it is that the CAIN can be validly compared. Parameters that require specification include species of animal (and, for certain species, the strain within the species)
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From page 254... ...
The forgoing presupposes that experiments are performed with nearly complete survival until a terminal sacrifice. In experiments where animals die spontaneously or where there has been excessive mortality prior to a terminal sacrifice, appropriate actuarial methods must be used to determine incidences of excess tumors.
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From page 255... ...
CAI's FOR HUMANS In order to use the CAl comparisons derived from animal data to provide indications of the relative carcinogenic potential of the same compounds in humans, a number of assumptions must be invoked. The following four assumptions, for example, will justify statements about the relative dangers of two compounds, for convenience called pesticide i and pesticidej, in humans: 1.
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From page 256... ...
Together, these four assumptions permit the calculation of equivalent doses from experimentally observed CAN'T. By virtue of the first three assumptions, for any low dose, Di, to which humans are typically exposed, Ih'~Dl)
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From page 257... ...
Yet they, or assumptions of comparable strength, must be invoked whenever the results of bioassays are used to compare the potencies in humans of different compounds. The above assumptions appear to be plausible approximations for compounds whose chemical and biological properties are not excessively dissimilar.
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