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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 3: Coccidioides Immitis
Pages 159-164

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From page 159...
... C immitis infections are most prominent in several geographic locations in the United States, primarily California, Texas, New Mexico, Arizona, Nevada.
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From page 160...
... Consideration of this population would result in differences in the calculations achieved with this model, but the uncertainties associated with doing so were thought to be quite extreme.
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From page 161...
... , the costs are calculated separately to allow for the effects of discounting, which will be different in infants (who might have a lag of many years until disease manifestations) and in migrants (some of whom will have much less of a lag between immunization and prevention of disease and the associated health care costs)
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From page 162...
... period Table A3-3 Health Care Costs Associated with Coccidioides Infection Cost Units %with per per Care Unit Case Form of Treatment Mild respiratory illness 50% $50 1.0 physician a Mild respiratory illness with erythema complications mild respiratory illness 100% $50 3.0 physician a, diagnostic a, medication b erythema nodosum / toxic 100% $100 2.0 physician b erythema / arthritis Pneumonia: outpatient only 100% $250 1.0 outpatient treatment (physician a and b, diagnostic a, medication b) Pneumonia self-limiting: inpatient self-limiting: outpatient Persistent/disseminated P/D: Inpatient 100% $4,000 2.0 P/D: outpatient: 3-year period 100% $50 7.0 100% $4,000 1.0 100% $250 1.0 inpatient treatment outpatient treatment (e.g., physician a and b, medication b, diagnostic a)
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From page 163...
... immitis were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $44.8 million. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the health care costs saved would be $6.3 million.
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From page 164...
... If a vaccine program were implemented today and the vaccine were 100% efficacious and utilized by 100% of the target population, the annualized present value of the cost per QALY gained is $85,000. Using committee assumptions of less-than-ideal utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the cost per QALY gained is $240,000.
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Key Terms

  • committee estimated
  • target population
  • respiratory illness
  • mild respiratory
  • care costs

  • committee assumptions
  • using committee
  • infectious diseases
  • including time
  • monetary costs

  • immitis infection
  • immitis infections
  • limited physician
  • qalys gained
  • physician visit

  • qaly gained
  • costs saved
  • disseminated infection
  • coccidioides infection
  • medical attention

  • program cost
  • seek medical
  • health utility
  • experiment station
  • illness mild

  • prolonged outpatient
  • protective efficacy
  • agricultural experiment
  • current population
  • outpatient phase


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