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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 4: Cytomegalovirus
Pages 165-172

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From page 165...
... The committee assumed 400 deaths annually from the congenitally acquired CMV infection, and 160 deaths from CMV infection in organ transplant patients. The treatment of HIV infection and AIDS and the effect of those changes in the health status and costs of care experienced by those with HIV has changed rapidly in recent years and is expected to continue to do so.
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From page 166...
... COST INCURRED BY DISEASE Table A4-2 summarizes the health care costs incurred by cytomegalovirus infections. For the purposes of the calculations used in the report, it was assumed that costs for neurologic sequelae of CMV infection in newborns (whether symptomatic at birth or not)
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From page 167...
... Table 4-1 summarizes vaccine development assumptions for all vaccines considered in this report. VACCINE PROGRAM CONSIDERATIONS Target Population The committee's model assumes that immunization with this vaccine will occur during puberty.
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From page 168...
... 168 a' Cd an EM Cat o o U
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From page 169...
... 169 O ~ ce cD ct ~ ~ ° o ,, 2 :, 5 ~C — o C~ O · ~ tD u, ~ ~ ~ O ~ ~ O ~C)
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From page 170...
... If a vaccine program for CMV were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $4 billion. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the health care costs saved would be $1 .1 billion.
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From page 171...
... READING LIST Demmler GJ. Acquired Cytomegalovirus Infections.
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Key Terms

  • cmv infection
  • severe sequelae
  • committee estimated
  • cmv disease
  • committee assumptions

  • transplant patients
  • using committee
  • care costs
  • congenital cytomegalovirus
  • monetary costs

  • target population
  • including time
  • severe cmv
  • organ transplant
  • neurologic sequelae

  • mild sequelae
  • cmv infections
  • normal lifespan
  • infectious diseases
  • congenitally acquired

  • life expectancy
  • qalys gained
  • acquired cmv
  • quality adjusted
  • cytomegalovirus disease

  • moderate cmv
  • vaccine development
  • summarizes vaccine
  • mental retardation
  • experience severe


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