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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 5: Enterotoxigenic E. coli
Pages 173-176

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From page 173...
... Disease Scenarios For the purposes of the calculation in this report, the committee assumed that the vast majority of infections manifest as mild to moderate diarrhea lasting 4 days and associated with a health utility index (HUI)
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From page 174...
... VACCINE PROGRAM CONSIDERATIONS Target Population The target population was estimated to include the annual birth cohort and overseas travelers. For the purposes of this report, the number of targeted travelers is 2,500,000 annually.
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From page 175...
... 175 s:: Ct o o a' CD ~ ~ Ct ~ V U~ ·_ o ~ V ~ s~ a~ U~ U~ o Cd V V au CQ Ct C~ .o v E~ ·3 .
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From page 176...
... Using committee assumptions of time and costs until licensure, the fixed cost of vaccine development has been amortized and is $7.2 million for a ETEC vaccine. If a vaccine program were implemented today and the vaccine were 100% efficacious and utilized by 100% of the target population, the annualized present value of the cost per QALY gained is $700,000.
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Key Terms

  • target population
  • committee assumptions
  • using committee
  • including time
  • monetary costs

  • vaccine development
  • qalys gained
  • qaly gained
  • program cost
  • summarizes vaccine

  • vaccines considered
  • committee estimated
  • program considerations
  • infections manifest
  • committee assumed

  • overseas travelers
  • low fever
  • moderate diarrhea
  • watery diarrhea
  • annual birth

  • abdominal cramps
  • etec infection
  • produce nausea
  • profuse watery
  • vaccine administration

  • program assumptions
  • birth cohort
  • cherry eds
  • fixed cost
  • mild cause


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