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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 11: Human Paillomavirus
Pages 213-222

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From page 213...
... The two distinct types of cells are mucosal HPV infection and cutaneous HPV infection. Genital tract HPV is thought to be currently the most common sexually transmitted viral infection in the United States.
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From page 214...
... COST INCURRED BY DISEASE Table All-2 summarizes the health care costs incurred by HPV infections. For the purposes of the calculations in this report, it was assumed that women with genital warts incur costs associated with physician visits and diagnostics.
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From page 215...
... ,000 10.0% 0.97 All Cancers: assume average 25-year lag from infection Cervicalcancer—carcinoma 25,000 5.0% in situ treatment phase posttreatment phase (follow-up) 0.85 0.5000 (6 months/ year)
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From page 216...
... All Cancers: assume average 25-year lag from infection Penile cancer—carcinoma 25,000 5.0% in situ treatment phase post-treatment phase (follow-up) Penile cancer locally invasive at diagnosis treatment phase (sur gery, radiation, chemo therapy)
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From page 217...
... . pnyslclan a diagnostic c ambulatory surgery physician a/year 100% $50 3 diagnostic a/year Cervical cancer-locally invasive at diagnosis treatment phase (sur- 100% $100 2 physician b gery, radiation, chemo therapy)
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From page 218...
... 100% $50 6 MEN Genital warts, limited diagnostic a/year minor physical discom- 100% $50 1 physician a fort minor physical discom fort; recurrences for 10 years Genital warts, extensive some physical discom fort Genital warts, extensive and recurring some physical discom- 100% fort 2 recurrences per year 100% for 10 years All Cancers: assume average 25-year lag from infection Penile cancer—carcinoma in situ treatment phase 100% $50 1 50% $1,000 1 100% $100 1 50% $4,000 1 100% $500 100% $100 100% $50 2 physician a/year 1 100% post-treatment phase (follow-up) Penile cancer locally invasive at diagnosis treatment phase (surgery, 100% radiation, chemotherapy)
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From page 219...
... chemotherapy physician a/year Penile cancer—advanced at diagnosis treatment phase (sur- 100% $100 1 physician b gery, radiation, che motherapy) 100% $4,000 1 hospitalization 100% $500 2 surgeon/anesthesiologist 50% $5,000 1 radiation 50% $5,000 1 chemotherapy poet-treatment phase 100% $100 6 physiciarlb/year (follow-up and seque lae (e.g., infertility, sexual dysfunction, urinary dysfunction)
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From page 220...
... If a vaccine program for HPV were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $530 million. Using committee assumptions of less than ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the health care costs saved would be $140 million.
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From page 221...
... Advance Report of Final Natality statistics, 1994. Monthly Vital Statistics Report 1996; 44.
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Key Terms

  • vaccine program
  • hpv infection
  • physical discomfort
  • committee assumptions
  • using committee

  • treatment phase
  • target population
  • including time
  • care costs
  • monetary costs

  • locally invasive
  • ideal efficacy
  • minor physical
  • physician visits
  • qaly gained

  • treatment patterns
  • posttreatment phase
  • cervical cancer
  • incur costs
  • human papillomavirus

  • penile cancers
  • approximately half
  • recurring genital
  • costs saved
  • cervical dysplasia

  • vaccine development
  • hpv infections
  • program cost
  • summarizes vaccine
  • recurrent warts


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