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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 15: Multiple Sclerosis
Pages 245-250

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From page 245...
... Some of the common signs of this disease include impaired vision, involuntary eye movements, speech impairments, weakened sense of vibration and position, ataxia and intention tremor, weakness or paralysis of one or more limbs, spasticity, and bladder complications. At the site of active lesions are accumulations of T-lymphocyte and monocyte macrophages around venules and at plaque margins where myelin is being destroyed.
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From page 247...
... COST INCURRED BY DISEASE Table A15-1 summarizes the health care costs incurred by MS. For the purposes of the calculations in this report, it was assumed that for all scenarios there is a diagnostic phase, followed by a treatment phase which lasts the duration of the patients lifetime.
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From page 248...
... Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the QALYs gained would be 15,~0. If a vaccine program for MS were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $830 million.
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From page 249...
... A negative value represents a saving in costs in addition to a saving in QALYs. Using committee assumptions of less-than-ideal utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the cost per QALY gained is -$1 1,000.
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  • diagnostic phase
  • costs saved

  • vaccine development
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  • summarizes vaccine
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  • treatment phase
  • impaired vision
  • sclerosis statistics

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