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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 18: Neisseria meningitidis
Pages 267-272

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From page 267...
... Table A18-1 illustrates the age distribution of new annual NMB infections. Disease Scenarios For the purposes of the calculations in this report, the committee estimated that 65% of new cases of NMB manifest as meningitis.
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From page 268...
... The committee estimated that 35°/O of new cases of NMB manifest as bacteremia and sepsis. Approximately half of these cases require ICU hospitalization, such as those with Waterhouse Friederichsen syndrome.
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From page 269...
... Table A18-3 summarizes the health care costs incurred by NMB infections. For the purposes of the calculations in this report, it was assumed that patients with meningitis incur costs associated with hospitalization (hospital costs, specialist physicians, diagnostics)
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From page 270...
... inpatient 100% $4,000 1.0 hospitalization 100% $100 3.0 physician b 100% $100 1.0 diagnostic b Bacteremia/Sepsis~omplica tions acute complications (cardiac, 100% $4,000 1.0 hospitalization disseminated intravascular coagulation, pneumonia, etc.) 100% $100 3.0 physician b 100% $500 1.0 diagnostic c 20% $7,000 1.0 amputation 20% $500 2.0 surgical staff 20% $3 000 1.0 rehabilitation experience neurologic sequelae incur costs associated with multiple visits per year to a specialist and therapists for the duration of their life.
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From page 271...
... meningitidis B were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $6 million. Using committee assumptions of less-than-ideal efficacy and utilization and
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From page 272...
... Milagres LG, Ramos SR, Sacchi CT, et al. Immune Response of Brazilian Children to a Neisseria meningitidis Serogroup B Outer Membrane Protein Vaccine: Comparison with Efficacy.
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Key Terms

  • target population
  • committee assumptions
  • using committee
  • acute complications
  • neurologic sequelae

  • committee estimated
  • neisseria meningitidis
  • including time
  • care costs
  • monetary costs

  • average age
  • experience complications
  • life expectancy
  • qalys gained
  • incur additional

  • qaly gained
  • adjusted life
  • incur costs
  • quality adjusted
  • nmb infections

  • nmb manifest
  • costs saved
  • vaccine development
  • complications incur
  • nerve damage

  • heart failure
  • program cost
  • summarizes vaccine
  • vaccines considered
  • cranial nerve


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