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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 19: Parainfluenza Virus
Pages 273-278

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From page 273...
... Disease Scenarios For the purposes of the calculation in this report, the committee assumed that PIV disease manifests as either a mild infection such as pharyngitis or otitis media, croup, or bronchiolitis/pneumonia. It was assumed that in children 2 years of age and under, the proportion of infections manifesting as those 3 disease scenarios is 70%, 20%, and 10% respectively.
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From page 274...
... outpatient 0.75 0.0082 (3 days) COST INCURRED BY DISEASE Table A19-2 summarizes the health care costs incurred by PIV infections.
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From page 275...
... APPENDIX 19 Table A19-2 Costs of Care for Parainfluenza Vines Infection 275 % with Cost per Units per Care Unit Case Form of Treatment AGE <2 Upper Respiratory pharyngitis, otitis media 100% $50 1.0 physician a 100% $50 1.0 diagnostic a 100% $50 1.0 medication b Croup outpatient only 100% $50 2.0 physician a 100% $50 1.0 diagnostic a 100% $50 1.0 medication b inpatient 100% $3000 1.0 hospitalization 100% $50 2.0 physician a 100% $50 1.0 diagnostic a 100% $50 1.0 medication b Bronchiolitis/pneumonia outpatient only 100% $50 2.0 physician a 100% $50 1.0 diagnostic a 100% $50 1.0 medication b Bronchiolitis/pneumonia inpatient 100% $4000 1.0 hospitalization 100% $50 2.0 physician a 100% $50 1.0 diagnostic a 100% $50 1.0 medication b AGE 2-64 Upper Respiratory pharyngitis, otitis media 50% $50 1.0 physician a 50% $50 1.0 diagnostic a 50% $50 1.0 medication b Bronchiolitis/pneumonia outpatient only 50% $50 2.0 physician a 50% $50 1.0 diagnostic a 50% $50 1.0 medication b AGE 65+ Upper Respiratory pharyngitis, otitis media 50% $50 1.0 physician a 50% $50 1.0 diagnostic a 50% $50 1.0 medication b Bronchiolitis/pneumonia outpatient only 50% $50 2.0 physician a 50% $50 1.0 diagnostic a 50% $50 1.0 medication b Bronchio litis/pneumonia inpatient 100% $4000 1.0 hospitalization 100% $50 2.0 physician a 100% $50 1.0 diagnostic a 100% $50 1.0 medication b
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From page 276...
... Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the QALYs gained would be 10,000. If a vaccine program for PIV were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $580 million.
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From page 277...
... A Live Human Parainfluenza Type 3 Virus Vaccine is Attenuated and Immunogenic in Healthy Infants and Children. The Journal of Infectious Diseases 1995; 172: 1445- 1450.
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Key Terms

  • target population
  • piv disease
  • committee assumptions
  • using committee
  • including time

  • monetary costs
  • otitis media
  • care costs
  • parainfluenza virus
  • parainfluenza viruses

  • costs saved
  • qalys gained
  • committee assumed
  • qaly gained
  • program cost

  • summarizes vaccine
  • vaccines considered
  • receive treatment
  • parainfluenza type
  • program considerations

  • hospitalization costs
  • disease ranges
  • live human
  • index associated
  • human parainfluenza

  • medical treatment
  • disease receive
  • piv infections
  • program assumptions
  • healthy infants


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