Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 21: Rheumatoid Arthritis
Appendix 21: Rheumatoid Arthritis
Pages 285-290
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From page 285... ...
The synovial inflammation can potentially destroy the cartilage and cause bone erosion, which subsequently leads to joint deformities. The destructive nature of this disease ranges from a brief oligoarticular illness with minimal joint damage to a more chronic, progressive polyarthritis with major joint deformity.
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From page 286... ...
COST INCURRED BY DISEASE Table A21-3 summarizes the health care costs incurred by RA. For the purposes of the calculations in this report, it was assumed that initial treatment for all RA patients includes 4 visits to a physician (half will seek the attention of a specialist)
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From page 287... ...
Benign short-term pain, resolved within 1 year 9,689 Moderate disability 41,986 joint involvement premature death: redu ction in life expectancy by 3 years Progressive seriously affected within 5-10 years of .
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From page 288... ...
Benign short-term pain, resol- 50% $50 4.0 physician a ved within 1 year 50% $100 4.0 physician b 100% $50 12.0 medication b 100% $500 1.0 diagnostic c Moderate disability initial treatment 50% $50 4.0 physician a 50% $100 4.0 physician b 100% $50 1.0 medication b 100% $500 1.0 diagnostic c annual care 50% $50 2.0 physician a 50% $100 2.0 physician b 100% $50 12.0 medication b 10% $3,000 1.0 hospitalization 10% $3,000 1.0 rehabilitation or other care Progressive initial treatment 50% $50 4.0 physician a 50% $100 4.0 physician b 100% $50 1.0 medication b 100% $500 1.0 diagnostic c annual care 100% $100 4.0 physician b 100% $50 12.0 medication b 25% $3,000 1.0 hospitalization 25% $3,000 1.0 rehabilitation or other care Severe systemic manifestations initial treatment 50% $50 4.0 physician a 50% $100 4.0 physician b 100% $50 1.0 medication b 100% $500 1.0 diagnostic c annual care 100% $100 6.0 physician b 100% $50 12.0 medication b 50% $3,000 1.0 hospitalization 50% $3 000 1.0 rehabilitation or other VACCINE PROGRAM CONSIDERATIONS Target Population For the purposes of the calculations in this report, it is assumed that the target population for this vaccine is all new cases of Rid. It was assumed that 90% of the target population would utilize the vaccine.
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From page 289... ...
If a vaccine program for rheumatoid arthritis were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $1 .4 billion. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the health care costs saved would be $300 million.
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From page 290... ...
Prashker MJ, Meenan RF. The Total Costs of Drug Therapy for Rheumatoid Arthritis: A Model Based on Costs of Drug, Monitoring, and Toxicity.
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