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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 23: Shigella
Pages 295-298

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From page 295...
... It was assumed that 25% of cases are in travelers from the United States to other countries. Disease Scenarios For the purposes of the calculation in this report, the committee assumed that shigella manifests as acute diarrhea lasting 6 days and associated with a health utility index of .51.
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From page 296...
... Table 4-1 summarizes vaccine development assumptions for all vaccines considered in this report. VACCINE PROGRAM CONSIDERATIONS Target Population For the purposes of the calculations in this report, two scenarios are discussed: a target population of travelers only and a target population of travelers and infants.
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From page 297...
... Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the program cost would be $550 million. Using committee assumptions of time and costs until licensure, the fixed cost of vaccine development has been amortized and is $7.2 million for a Shigella vaccine.
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Key Terms

  • target population
  • committee assumptions
  • using committee
  • including time
  • monetary costs

  • care costs
  • costs saved
  • vaccine development
  • qalys gained
  • oral rehydration

  • qaly gained
  • program cost
  • shigella infection
  • summarizes vaccine
  • vaccines considered

  • notifiable diseases
  • deaths associated
  • program considerations
  • committee assumed
  • shigella manifests

  • pediatric infectious
  • shigella incur
  • incur costs
  • program assumptions
  • acute diarrhea

  • cherry eds
  • fixed cost
  • health utility
  • diarrhea lasting
  • development assumptions


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