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Vaccines for the 21st Century A Tool for Decisionmaking (2000) / Chapter Skim
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Appendix 24: Streptococcus, Group A
Pages 299-304

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From page 299...
... See Table A24-1. Disease Scenarios For the purposes of the calculation in this report, the committee assumed that 100% of noninvasive GAS infections result in a limited morbidity lasting 4 days and associated with a health utility index (HUI)
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From page 300...
... COST INCURRED BY DISEASE Table A24-3 summarizes the health care costs incurred by GAS infections. For the purposes of the calculations in this report, it was assumed that all pa
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From page 301...
... The costs for severe Fasciitis are approximately twice that for moderate fasciitis. Lifelong sequelae associated with Necrotizing Fasciitis were presumed to occur in most patients and were associated with yearly aftercare costs in approximately half of the patients.
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From page 302...
... All patients with toxic shock were presumed to also require outpatient visits to a specialist and additional medication. Other forms of invasive disease were presumed to be associated with a hospitalization and subsequent outpatient visits to a specialist and additional medication.
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From page 303...
... Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the health care costs saved would be $185 million. If a vaccine program for group A streptococci were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the program cost would be $720 million.
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From page 304...
... RD Feigin and JD Cherry eds. Philadelphia, PA: WB Saunder Company, 1992,pp.12961305.
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Key Terms

  • target population
  • gas disease
  • committee assumptions
  • using committee
  • toxic shock

  • rheumatic fever
  • including time
  • care costs
  • monetary costs
  • committee assumed

  • noninvasive gas
  • require hospitalization
  • acute rheumatic
  • invasive gas
  • life expectancy

  • qalys gained
  • quality adjusted
  • chronic rheumatic
  • costs saved
  • vaccine development

  • program cost
  • additional medication
  • summarizes vaccine
  • gas vaccine
  • vaccines considered

  • incidence rate
  • outpatient visits
  • necrotizing fasciitis
  • gas infections
  • disease seek


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