Biographical Memoirs Volume 46 (1975) / Chapter Skim
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9. Clarence Cook Little
9. Clarence Cook Little
Pages 240-263
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From page 241... ...
A leader in education, in the national effort to understand and control cancer, and in the development of mammalian genetics, Dr. Little inspired in the many people who knew him not only admiration but warm personal friendship.
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From page 242... ...
The mouse was a logical choice for inbreeding experiments with a mammal, perhaps, in fact, an especially fortunate choice, since wild populations of mice form small colonies with considerable inbreeding so that the accumulation of deleterious recessive genes is restricted. But successful establishment of a homozygous strain required careful selection from a colony of adequate size.
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From page 243... ...
The genetic uniformity of these and the dozens of other lines subsequently produced in many laboratories makes them a research tool of major importance. The C57BL strain heads the list in popularity—worldwide annual use certainly exceeds one million mice.
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A plan to enroll all freshmen and sophomores in a separate University College under its own dean encountered a barrage of faculty criticism and was dropped. Lack of funds rather than active opposition was principally responsible for the demise of a plan for the erection of dormitories housing a few instructors or professors as well as students and designed to serve as small residential colleges.
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From page 245... ...
Another project took advantage of the great difference in mammary tumor incidence between some of the inbred strains. In a cross between high and low strains, it was found that tumor incidence of the first hybrid generation was determined by the maternal parent.
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From page 246... ...
The research continued, but on a curtailed basis while the staff turned to fishing, gardening, and canning to provide food. It was at this time that the laboratory initiated the sale of its inbred strains to other investigators, an activity that ultimately became both a major service to researchers all over the world and a much needed source of uncommitted income.
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From page 247... ...
Part of the staff moved to temporary quarters in other laboratories, part to a remodeled barn on a summer estate that had been donated earlier. The inbred strains of mice flooded back from laboratories around the world, and potential grantors heard, as they never would have otherwise, of their essential value to hundreds of researchers.
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From page 248... ...
He was twice president of the American Association of Cancer Research and was influential in creating Cancer Research as its official journal. At one time or another he also served as president of the American Eugenics Society, the American Birth Control League, and the American Euthanasia Society.
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From page 249... ...
He was the recipient of numerous honorary degrees. The Clarence Cook Little Hall at the University of Maine, the Clarence Cook Little Science Building at the University of Michigan, and most recently the Clarence Cook Little Library and Conference Center at The Jackson Laboratory were named in his honor.
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From page 250... ...
Of necessity, Dr. Little's personal participation in these projects decreased as his executive duties increased.
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From page 251... ...
Journal of Cancer Research I
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From page 252... ...
Further experimental studies on the inheritance of susceptibility to a transplantable carcinoma ~WA) of the Japanese waltzing mouse.
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of the Japanese waltzing mouse. Science, 51:467-68.
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~ ~ . ~ ~ ~ ~ — A report of a histological Truly OI one eyes ana gonads ot mice treated with a tight dockage of x-rays.
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1927 255 Commonwealth Preliminary report on a species cross in rodents, Mus musculus x Mus wagneri. Papers of Michigan Academic Sciences, Arts and Letters, 8: 393-99.
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From page 256... ...
The relation of coat color to the spontaneous incidence of mammary tumors in mice.
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Extrachromosomal influence in relation to the incidence of mammary and non-mammary tumors in mice.
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Chromosomal and extrachromosomal influence in relation to the incidence of mammary tumors in mice.
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Observations on the mammary tumor incidence in mice born from transferred ova. Cancer Res., 2:525-30.
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The incidence of adrenal cortical carcinoma in gonadectomized female mice of the extreme dilution strain: II. Observations on the accessory sex organs.
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Alexander Blain Hospital Bulletin, 5:1-7. Parental influence of mammary tumor incidence.
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1958 Biological aspects of cancer research.
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From page 263... ...
Comparative virulence of the mammary tumor agent from different sources; qualitative and quantitative differences.
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