(NAS Colloquium) Genetic Engineering of Viruses and Viral Vectors (1996) / Chapter Skim
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Genetic engineering of viruses and of virus vectors: A preface
Genetic engineering of viruses and of virus vectors: A preface
Pages 11287-11287
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These considerations serve as the foundation of the idea that it should be possible to construct highly modified, attenuated, viruses that target specific cells and to introduce into the targeted cells desired functions deliberately incorporated into the viral genomes. These functions include the potential to selectively destroy cancer cells by "hit-and-run" viruses that in this instance would be eliminated by the immune system once their task is done, or to establish lifelong latency concomitant with the expression of a cellular gene necessary for the survival of the infected cell.
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