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(NAS Colloquium) Genetic Engineering of Viruses and Viral Vectors (1996) / Chapter Skim
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Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma
Pages 11302-11306

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From page 11302...
... Cell Biology and "Pathology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030 ABSTRACT Recombinant adenoviral mediated delivery of suicide and cytokine genes has been investigated as a treatment for hepatic metastases of colon carcinoma in mice. Liver tumors were established by intrahepatic implantation of a poorly immunogenic colon carcinoma cell line (MCA-26)
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From page 11303...
... Combination Suicide and IL-2 Gene Therapy for Hepatic Metastases of Colon Carcinoma. Adenoviral mediated gene transfer of mIL-2 into the tumor was synergistical with HSV-tk and induced a systemic antitumor immunity that resulted in the further regression of the hepatic tumor as well as protection against distant site challenges of parental tumor cells (18~.
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From page 11304...
... IL-12 Mediated Gene Therapy of Metastatic Colon Carcinoma. IL-12 is known to enhance the cytolytic activity of a number of immune effecter cells including NK cells, lymphokine-activated killer cells, T cells and macrophages (21-24~.
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From page 11305...
... This additional treatment can potentially enhance the antitumoral efficacy of IL-12 and induce a long-lasting systemic antitumoral immunity. The results obtained with a poorly immunogenic tumor are encouraging for the further development of in vivo gene therapy as a treatment modality for metastases from colon cancer in humans.
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From page 11306...
... (1994) Cancer Res.
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Key Terms

  • gene therapy
  • cancer cells
  • recombinant adenoviral
  • adenoviral vectors
  • intratumoral injection

  • metastatic colon
  • antitumoral immunity
  • adenoviral vector
  • suicide gene
  • tumor volume

  • hepatic tumors
  • ribosome entry
  • survival time
  • hepatic tumor
  • effector cells

  • colon cancer
  • hepatic metastases
  • sarcoma virus
  • simplex virus
  • immune response

  • internal ribosome
  • cell line
  • herpes simplex
  • intrahepatic cancer
  • liver metastases

  • entry site
  • systemic antitumoral
  • seven days
  • animals treated
  • virus type


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