(NAS Colloquium) Genetic Engineering of Viruses and Viral Vectors (1996) / Chapter Skim
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The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors
The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors
Pages 11313-11318
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From page 11313... ...
In a syngeneic scid mouse intracranial tumor model, recombinant herpes simplex virus can be experimentally used for the treatment of brain tumors. These viruses and additional engineered viruses were subsequently tested in human glioma cells both in vitro and in viva.
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From page 11314... ...
However, certain genetically engineered HSV lack neurovirulence and, thus, may be safe for direct intratumoral administration. The rationale for using modified HSV as experimental antiglioma agents has resided in the fact that these viruses retain the ability to replicate in dividing tumor cells but are avirulent in the surrounding terminally differentiated cells of the CNS (which lack enzymes required for virus replication)
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From page 11315... ...
Both U251MG and D54MG cells were used as intracranial glioma xenograft with 106 glioma cells implanted as described previously. Untreated scid mice injected intracranially with U251MG cells had an average median survival rate of 34 days, whereas mice receiving D54MG cells became moribund at a more rapid rate with an average median survival of 20 days.
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From page 11316... ...
2. Kaplan-Meier survival plots for scid mice injected intracranially with 106 D54MG human glioma cells, followed by R4009 inoculation 5 days later into the tumor bed.
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From page 11317... ...
4. Kaplan-Meier survival plots of C.B.-17 scid/scid mice injected intracranially with D54MG human glioma cells and treated 5 days later with 2 X 10> pfu (v)
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From page 11318... ...
11318 Colloquium Paper: Andreansky et al. Robertson, J
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