(NAS Colloquium) Genetic Engineering of Viruses and Viral Vectors (1996) / Chapter Skim
Currently Skimming:
Replication-defective herpes simplex virus vectors for gene transfer in vivo
Replication-defective herpes simplex virus vectors for gene transfer in vivo
Pages 11319-11320
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 11319... ...
Experimental studies in rats have demonstrated relatively efficient and robust transient transgene expression in brain after direct intracranial inoculation with a number of different vectors. Although singly deleted viruses are toxic to neurons in culture, animals uniformly survive direct injection of these replication-defective or incompetent vectors into brain with only minor pathologic evidence of cell loss.
|
From page 11320... ...
A surprising finding that has emerged recently in studies of the multiply deleted viruses is that there appears to be a "failure" of remaining IE gene shutoff in these vectors, with HCMV-driven transgene expression persisting in a similar fashion. The triply deleted (THZ.2)
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.