(NAS Colloquium) Genetic Engineering of Viruses and Viral Vectors (1996) / Chapter Skim
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Applications of pox virus vectors to vaccination: An update
Applications of pox virus vectors to vaccination: An update
Pages 11349-11353
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From page 11349... ...
Initial safety concerns of vaccinia virus vectors have been addressed by the use of highly attenuated replication-deficient strains of the virus as well as the engineering of host range-restricted pox viruses such as canarypox virus that, while restricted for productive replication to avian species, have been shown to effectively vaccinate nonavian targets. The initial studies on vaccinia virus were extended to other members of the pox virus family so as to provide species specific vectors.
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From page 11350... ...
Canarypox virus recombinants expressing the measles virus fusion and hemagglutinin glycoproteins have been used to vaccinate dogs. Comparison of these recombinants with vaccinia virus vectors expressing the same genes were shown to provide similar levels of immune response and protection against a challenge with the related Morbilli virus, canine distemper (13~.
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From page 11351... ...
The modified NYVAC vector, while highly attenuated, retained the ability to induce protective immune responses to foreign antigens in a fashion similar to the thymidine kinase mutant of the parent strain. A number of examples using the NYVAC vector as a recombinant vaccine delivery system have been provided in animal model systems and in target species including humans.
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From page 11352... ...
To date, all the above-mentioned abstracted data provided from human clinical trials using NYVAC-based vectors have described a good safety profile and the induction of some level of immunity to the expressed heterologous antigens. Other Applications of Pox Virus-Based Vectors The use of pox virus-based vectors as recombinant vaccines for heterologous bacterial, viral, or parasitic pathogens was the first practical application of this technology deriving from the fact that vaccinia virus was an established vaccine.
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From page 11353... ...
AIDS Res.
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