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(NAS Colloquium) Genetic Engineering of Viruses and Viral Vectors (1996) / Chapter Skim
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Early events in poliovirus infection: Virus-receptor interactions
Pages 11378-11381

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 11378...
... All viruses initiate infection of susceptible cells by first binding to a cell surface receptor. For some viruses, the cell receptor plays an active role in the uncoating of the viral genome, whereas for others the receptor is nothing more than a tether that concentrates virus particles on the cell surface and directs them toward disassembly pathways.
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From page 11379...
... . The Ca phenotype maps to a central region of the viral RNA encoding nonstructural proteins, suggesting that the block to replication in wild-type P1/Mahoney is past the stage of cell entrypossibly RNA replication, proteolytic processing, or even assembly.
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From page 11380...
... Sphingosine (spin) in the hydrocarbon-binding pocket is shown as blue spheres srr mutations are shown as a white line labeled contact region, and adapting mutations are shown as yellow spheres and their amino acid residues are given (e.g., 1095, residue 95 of Vim.
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From page 11381...
... These experiments will provide clues about how cell receptors participate in the uncoating of an icosahedral virus. Work cited from my laboratory has been supported by the National Institutes of Health and the American Cancer Society.
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Key Terms

  • viral rna
  • binding site
  • cell surface
  • cell receptor
  • unpublished data

  • poliovirus binding
  • receptor binding
  • bind poliovirus
  • soluble pvr
  • capsid residues

  • particle formation
  • srr mutations
  • hela cells
  • mutant pvrs
  • adapting mutation

  • binding affinity
  • viral variants
  • viral capsid
  • structural changes
  • insect cells

  • poliovirus receptor
  • surface receptor
  • cell receptors
  • cytoplasmic domain
  • site defined

  • binding pocket
  • conformational changes
  • initiate infection
  • cell membrane
  • capsid sequences


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