Biographical Memoirs Volume 51 (1980) / Chapter Skim
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William Barry Wood, Jr.
William Barry Wood, Jr.
Pages 386-418
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Ban ~/ .
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HIRSCH BARRY WOOD was born May 4, 1910 in Milton, Massachusetts, of parents from established Boston families. His father was a Harvard graduate and a business man.
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He graduated summa cum laucle and did honors thesis research in biochemistry as ~ shall discuss in a moment. Barry was asker!
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To be allowed to work in his laboratory was a tremendous privilege." Barry's honors thesis work was selectecl to take advantage of his athletic as well as his academic activities. The laboratory had studied previously changes in certain physiological or biochemical parameters in athletes such as marathon runners.
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This thesis work, properly evaluated and written up, was published in a German physiology journal and was the first of a long series of publications by W Barry Wood, Jr., nearly all of which had to do directly or indirectly with the same white cells that were the subjects of this college project.
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They kept careful records of expenses; total costs, including tuition, room and board, and maintenance on a secondhand car, were Al 100 for the first year, for both! The medical school curriculum was a demanding one, but Barry found some time to spend in the laboratory of W
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When graduation from meclical school drew near, Barry found himself facing a cliff~cult choice in terms of postdoctoral training. He was interested in everything ranging from clinical medicine through clinical research to the basic sciences ant!
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They demonstrates! that leukocytes played a primary role in recovery from pneumococcal pneumonia and were not merely scavenger cells that cleaned up the damage after antibodies or other agencies had killed the microbes.
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Each was the professor in charge of clinical and administrative duties for six months of the year, during which the time available for research was nil, or at best catchas-catch-can, and each enjoyed six months of the year for fulItime research, uninterrupted! save by emergencies.
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He studies! the mechanisms by which the outcome of experimental pneumococcal pneumonia was altered by various agencies: coexisting influenza virus infections, various drugs and antibiotics,-and serum antibodies.
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396 BIOGRAPHICAL MEMOIRS on a new line of research, leaving pneumococcal disease in favor of experiments dealing with what appeared to be quite a different area, the pathogenesis of fever. When asked to comment on the factors that accounted for this change in direction of his research, Wood began his reply with another comment on his visit, during his house-officer days at Hopkins, with Oswald Avery at The Rockefeller Institute.
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WILLIAM BARRY WOOD, JR. 397 At this time Wood changed not only his primary field of Interest, but also his job.
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Wood was also a declicated member of The American Society for Clinical Tnvestigation and the Association of American Physicians, serving as President of both. One outside activity deserves special mention, for it was an unusual one and one that Barry prizes!
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With passage of time junior people from the three departments moved into positions of indepenclence. These alumni continued to participate in the Pus Club meetings, and the meetings grew larger and larger, but the special quality persisted.
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His reputation as a scientist and as an excellent writer and speaker led to many invitations for review articles or name lectureships. He authored two articles in Scientific American, "White Cells and Bacteria," in 1951 and "Fever" in 1957; he gave a Harvey Lecture entitIecI "Studies on the Cellular Immunity of Acute Bacterial Infections" in 195 I; he contributed to Physiological Reviews in 1960 an article entitles!
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Then came the final, fatal heart attack on March 9, ~ 97 I, while Barry was in Boston to attend a dinner honoring President Pusey. His life thus encled in Boston where it had starter!
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Barry's unique combination of talent in teaching, research and clinical medicine, together with his sense of humility and natural benevolence of spirit, gave him that degree of wisdom which is the basis of effective leadership. Polly Bunting wrote: ~ harm thy AIDE ~ AAC&~_ ~Al`J~Al~ VIA .
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The last point made by Walsh McDermott, that Barry was convinced that it was the personal relationship that counted, is borne out by Barry's own remarks when he reviewed his career shortly before his cleath. In a response to a question from Dr.
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are: his unusual endowment of physical and mental talent and the drive to make the best use of these talents, a genuine interest in other people and extraordinary ability to influence them for their own good, and versatility- an MI-American triple threat in his career accomplishments as well as in his college football clays. The many direct quotations from Barry Wood contained in this memoir are all derived from a motion picture made only two months before his death.
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WILLIAM BARRY WOOD, JR. 405 the only thing I'c!
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Louis, Missouri, 19531955 Walter Reed Army Medical Center, Consultant, 1953-1960 Board of Trustees, Rockefeller Foundation, 1954~1971 Armed Forces Epidemiological Board, Commission on Epidemiological Survey, 1954-1964, 1966-1969 Medical Fellowship Board, National Research Council, 195~1957 Interurban Clinical Club, Honorary member, 1956-1971 National Academy of Sciences, elected 1959; Council member 1959-1965 National Advisory Allergy and Infectious Diseases Council, 19571961 Dartmouth Medical School Policy Committee, 1957-1962 The President's Science Advisory Committee, 196~1962 Visiting Committee of the Medical Department, Brookhaven National Laboratory, 1962-1964 Scientific Advisory Committee, Massachusetts General Hospital, 1961-1963 Advisory Committee, Mount Sinai Hospital, 1961- 1964 World Health Organization, 1963-1964 Armed Forces Epidemiological Board, Commission on Radiation and Infection, 1963-1964 Advisory Committee, Milton S Hershey Medical Center, 19631964
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WILLIAM BARRY WOOD, JR. 407 Board of Advisory Editors of The Journal of Experimental Medicine, 1963-197 1 Society for Experimental Biology and Medicine American Society for Microbiology Population Crisis Committee, 1967
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III. The mechanism of recovery from pneumococcal pneumonia in patients treated with sulfapyridine.
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The action of type-specif~c antibody upon the pulmonary lesion ot experimental pneumococcal pneumonia. Science, 92:15.
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1946 With Carl G Harford, Mary Ruth Smith, and C
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With Mary Ruth Smith. Surface phagocytosis—its relation to the mechanism of recovery in acute pneumonia caused by encapsulated bacteria.
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Presented March 1951 to the Basic Science Course, Army Medical Service Graduate School, Walter Reed Army Medical Center, Wash., D.C. The role of surface phagocytosis in acute bacterial infections.
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With Mary Ruth Smith. Surface phagocytosis.
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Med., 1 00:4 1 7-24. 1955 With Elisha Atkins, Fred Allison, fir., and Mary Ruth Smith.
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With Sister Marie Judith Foley and Mary Ruth Smith. Studies on the pathogenicity of group A streptococci I
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IX. The production of endogenous pyrogen by polymorphonuclear leucocytes.
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XII. Electrolytic factors influencing the release of endogenous pyrogen from polymorphonuclear leucocytes.
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S Shin and Mary Ruth Smith.
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