A Review of the Department of Defense's Program for Breast Cancer Research (1997) / Chapter Skim
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5 The Funded Portfolio of the 1993/1994 and 1995 BCRP Award Cycles
5 The Funded Portfolio of the 1993/1994 and 1995 BCRP Award Cycles
Pages 65-85
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From page 65... ...
The final section examines how the portfolio of funded research compares to the research areas formulated and recommended by the 1993 IOM report. RESEARCH PROJECTS During the FY 1993/1994 funding cycle, the U.S.
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DOD'S PROGRAM FOR BREAST CANCER RESEARCH 87% CIAO? 76% r....,.f approximately 78% of the funds ($170.9 million)
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To meet programmatic goals, some proposals with relatively high technical merit scores were not recommended for Finding, while some with lower technical merit scores were. The USAMRMC reported to the 1997 TOM 1600 400 ~ 200 .- ~ 000 c, u' o o 800 600 400 200 oL O Number of proposals received Number scoring 2.9 or better E3Number of awards recommended by IP 439 276 P-== _ _~ 1,487 1 on IDEA NIA OIA Funding Mechanism FIGURE 5-2.
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From page 68... ...
Among subject areas/disciplines, an approximately equal proportion of proposals received was ultimately recommended for awards, but health care delivery and epidemiology scored highest with 16% of applications recommended for funding. In the 1995 funding cycle the distribution of awards across subject areas and disciplines was similar to that in FY 1993/1994, except for radiology which included set-aside funds for mammography research (Table 5-21.
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The IF recommended against allocating any funds because relatively few scientifically meritorious infrastructure research proposals were received during the FY 1993/1994 funding cycle, and because the breast cancer infrastructure was perceived as currently solidly funded (USAMRMC, 1996c)
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of Proposals Received No. of Awards Recommended by IP 60 (13%)
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The committee also recommended that $3 million be spent on individual predoctoral fellowships to attract talented graduate students to breast cancer research and that $6 million be allocated for postdoctoral fellowships to allow fellows either to extend ongoing research related to breast cancer or broaden the scope of their research to include work relevant to breast cancer. During the 1993/1994 funding cycle, $19.7 million (9% of funds for awards)
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The proportion of training and recruitment proposals in epidemiology, psychosocial sciences, and health care delivery significantly exceeded this proportion, with 13% of proposals received and 15% of the banded portfolio. On the other hand, cell and tissue biology, molecular biology, and immunology represented 65% of all training grants received and funded, while clinical and chemotherapy proposals were 9% of those received and 6% Of those funded.
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Molecular biolog " For the 1993/1994 funding cycle, the subject area/disciplines represented by proposals were determined by the Science Applications International Corporation. h Proposals scoring 2.9 or better.
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Breast cancer center funds were directed toward developing patient-centered care in breast cancer centers and increasing access of breast cancer patients to clinical trials of new cancer therapies. In 1995, 11 proposals for breast cancer centers were received, of which 6 had scientific merit scores in the fundable range (scientific peer review score of 2.9 or better)
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FUNDING FOR PROGRAM ADMINISTRATION Funds for program adm~nis~ation cover review of scientific merit and program relevance; review of human use, animal use, and environmental/safety protocols; and up to four years of grant/contract performance monitoring (including site visits)
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SOURCE: USAMRMC, 1996c. For the 1995 funding cycle, 5.9°/O of allocated funds went toward program management (USAMRMC, 1997~.
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To ensure that men with breast cancer were not excluded from consideration, the language of the BAA was made gender-neutral. The fundamental question relating to epidemiology was reworded to include all types of epidemiological research not only molecular epidemiology research, but also more traditional epidemiological research, including epidemiological studies to investigate the role of endogenous and exogenous risk factors in the development of breast cancer.
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From page 80... ...
Funding of studies relating to delivery of health services and psychosocial impact was at almost the same level in FY 1995 as in FY 1993/1994; in addition, three special breast cancer centers were funded in FY 1995. Conversely, during the 1995 funding cycle, there were no awards for predoctoral training programs or for enhancement of breast cancer research infrastructure.
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For both the 1993/1994 and 1995 funding cycles, the distribution of grants among research subject areas for NIAs, IDEA grants, and OIAs were similar, with the largest proportion of research grants directed toward investigations of genetic alterations and cellular and molecular changes in breast cancer. During the 1993/1994 funding cycle, most research awards were directed at the first of the five research areas genetic alterations and cellular and molecular functions in breast cancer.
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From page 82... ...
As discussed above, the six fundamental research questions, as originally formulated by the 1993 IOM committee, did not encompass standard or classical epidemiology. The 1993 IOM report emphasized the need for molecular epidemiology studies, that is, studies that related epidemiological findings to changes occurring at the genetic, molecular, and cellular levels.
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84 o ._ or C~ ~ Cd o Cat Cd U
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h 0IA = Other Investigator-Initiated Awards; NIA = New Investigator Awards; IDEA = Innovative Developmental Exploratory Awards; CDA = Career Development Awards; PREF = Predoctoral Fellowships; POST = Postdoctoral Fellowships; DEMO = Demonstration Projects.
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