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Review of Acute Human-Toxicity Estimates for Selected Chemical-Warfare Agents (1997) / Chapter Skim
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Pages 68-70

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From page 68...
... USE OF THE ECt50 The ECtso, expressed as milligrams per cubic meter times exposure duration, is the effective vapor exposure at which 50% of the individuals exhibit a specified biological effect. The ECtso is the concentration that causes an effect in 50% of the population (that is, the median exposure of the distribution)
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From page 69...
... With some human data available, exposure estimates of the ECtso are probably within a factor of 2 of the true value. With this uncertainty and the steep dose-response curves observed, the true risk at the estimated ECts for humans can vary from nearly ~ % to nearly 99% .
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From page 70...
... estimated ECts could vary from less than 1% to nearly 50%. With only sparse animal data, the uncertainty of exposure estimates might be as much
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Key Terms

  • animal data
  • vapor exposure
  • lognormal distribution
  • human data
  • biological effect

  • true value
  • specified biological
  • density distribution
  • estimated exposure


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