Review of Acute Human-Toxicity Estimates for Selected Chemical-Warfare Agents (1997) / Chapter Skim
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Some human-toxicity estimates are available for the most common CW agents organophosphorus nerve agents and vesicants; however, most of those estimates were developed for offensive purposes (that is, to kill or incapacitate the enemy) and were intended to be interim values only.
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in the 1994 report entitled Review of Existing Toxicity Data arm Human Estimates for Selected Chemical Agents and Recommended Human Toxicity Estimates Appropriate for Defending the Soldier, the team concluded that some of the existing human-toxicity estimates are too high and are inappropriate for use in protecting soldiers. In those cases, CDEPAT proposed new estimates for various routes of exposure- percutaneous vapor, vapor inhalation, and percutaneous liquid exposures.
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The existing human-toxicity estimates were based on experiments performed 30-40 years ago using various animal species in often poorly controlled studies with vastly different protocols. In reviewing the available toxicity data for the six CW agents, the subcommittee recognized that the quality of the relevant toxicity data is marginal, but it also recognized that the Army needs "best estimates" to protect its troops from exposure.
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· Define the adequacy of the design in determining the toxicity values for healthy female as well as healthy male military personnel. · Define the requirements for observation of reversibility of adverse health effects.
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