Emerging Technologies for Nutrition Research Potential for Assessing Military Performance Capability (1997) / Chapter Skim
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Emerging Technologies for Nutrition Research, 1997 Pp.
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maintain and promote cell function. How this complex balance behaves when subjected to stress is a matter of great importance.
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Figure 19-1 Organ physiology as a function of cell biochemistry. An idealized model of organ and cell function is expressed in which injury increases over a period of time.
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action(s)
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PRACTICAL ISSUES IN ASSESSING CELL FUNCTION Studies on cell energy metabolism can be performed with in vivo or ex vivo preparations. There is a general trade-off between the ability to acquire mechanistic data and the complexity of the model system.
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choosing a cell model to examine the fast responses associated with hypoxia, two general requirements exist: (1) the cell should derive its energy in a manner similar to the tissue of interest, and (2)
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Figure 19-2 Cellular proton production. Protons are generated through various metabolic pathways.
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and/or dysfunction. With reference to the intestinal barrier function, such a sequence of events has been implicated in setting off a cascade of events associated with various systemic inflammatory responses and/or sepsis (Brinkmann et al., 1996)
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extensive in the Hep-G2 cell line, suggesting either 100 percent injury for approximately 50 percent of one or more subpopulations, or a sublethal, approximately 50 percent injury dispersed over the entire cell population(s)
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Figure 19-3 Effects of dinitrophenol (DNP) on metabolic rate of Caco-2 cells.
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Figure 19-4 Effects of dinitrophenol (DNP) on metabolic rate of primary rat liver hepatocyte cells.
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Substrate Flux during Hypoxic Stress Is there a preferential use of substrates during hypoxic stress? If certain substrates are used to the exclusion of others, a nutritional formulation could be developed to potentiate beneficial metabolic pathways.
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Gutierrez, G., and S Brown 1996 Gastrointestinal tonometry: A monitor of regional dysoxia.
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rived hepatocytes with specific requirements for a collagen matrix or other suitable support. One of several unique properties of the WIF-B cells is ease of propagation and convenience relative to primary cell harvesting.
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