Emerging Technologies for Nutrition Research Potential for Assessing Military Performance Capability (1997) / Chapter Skim
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Pages 417-430
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Emerging Technologies for Nutrition Research, 1997 Pp.
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proximal mediators in the proinflammatory cascade, but they also induce secondary inflammatory mediators such as IL-8, some of the macrophage inflammatory proteins, and the neutrophil adherence proteins (Fong et al., 1990a)
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of an inflammatory response when it is unknown or unclear whether cytokines are mediating a beneficial or an adverse effect. The question at hand is whether blood or urinary cytokine measurements can be used to make decisions regarding therapy or performance in a field setting.
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did not become septic, which survived, and which died, and these were compared with the frequency of being able to detect TNF-α in the circulation. Statistically, there was a greater frequency of detecting TNF-α in the serum of septic patients compared with nonseptic patients.
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FACTORS INFLUENCING THE MEASUREMENT OF PLASMA CYTOKINES A question that arises is why plasma measurements of TNF-α and IL-1 are poor indicators of their production. It must be emphasized that the question is not really whether TNF-α and IL-1 are being produced during sepsis and systemic inflammatory response syndromes.
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Unpublished data from studies that this laboratory has done with Greg Schultz's group at the University of Florida, looking at the levels of TNF-α in nonhealing wounds (decubitus ulcers or diabetic foot ulcers) , are similar (Unpublished data, L
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functional type I IL-1 receptor and also is released after acute inflammation (Hannum et al., 1990)
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The authors report a similar pattern with TNF-α (Sprenger et al., 1992)
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stimulus, or partial gastrectomy, which is a less severe, although still considerable, inflammatory insult. Urinary IL-6, p75, and IL-1ra excretion were significantly higher in patients undergoing esophagectomy, corresponding to the magnitude of surgical injury.
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Colotta, F., F
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Marano, M.A., Y
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Suter, P.M., S Suter, E
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Sprenger article (Sprenger et al., 1992) , they normalized for changes in the osmolality of the urine.
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DOUGLAS WILMORE: A final question. C-reactive protein2 pretty much mirrors IL-6 and may be a much easier assay.
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